ArticleAmerican journal of cancer research2025
Enhanced diagnostic accuracy of contrast-enhanced ultrasound in liver space-occupying lesions: superior sensitivity and specificity over conventional ultrasound.
Article in American journal of cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Epstein-Barr virus-positive inflammatory follicular dendritic cell sarcoma of the liver: clinical features, imaging findings and potential diagnostic clues.Abdominal radiology (New York) · 2026Article
- A Non-Invasive Integrated Model for Accurate Preoperative Identification of the Aggressive Macrotrabecular-Massive Subtype of Hepatocellular Carcinoma: A Single-Center Retrospective Study.Diagnostics (Basel, Switzerland) · 2026Article
- Feasibility of intraoperative Doppler ultrasound for intersegmental plane identification in pulmonary segmentectomy: a retrospective preliminary validation study.Journal of thoracic disease · 2025Article
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3 authors.
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Abstract
aimsTo evaluate the clinical value of contrast-enhanced ultrasound (CEUS) in diagnosing liver space-occupying lesions.
methodsA total of 487 patients with liver space-occupying lesions were examined using both conventional ultrasound and CEUS. The diagnostic results from the two methods were compared, with pathological findings used as the gold standard. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and the area under the receiver operating characteristic curve were calculated for each method to assess their diagnostic value.
resultsAmong the 487 lesions, 220 were malignant and 267 were benign. The relative blood flow (rBF) in the arterial phase of malignant lesions was significantly higher than that of benign lesions, while the rBF in the delayed phase was significantly lower (P<0.05). In diagnosing malignant lesions, CEUS had a higher detection rate than conventional ultrasound (75% vs. 43.18%, P<0.001). CEUS also demonstrated a higher diagnostic agreement for lesions ≤1 cm compared to conventional ultrasound (85.16% vs. 49.47%, P<0.001). The accuracy, sensitivity, specificity, PPV, and NPV of CEUS were all higher than those of conventional ultrasound (all P<0.05).
conclusionCEUS is effective in diagnosing liver space-occupying lesions, with superior sensitivity and specificity compared to conventional ultrasound.
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