ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2025
Neuropad Assessment of Sudomotor Function Across Glycemic Levels in Adults.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: To evaluate the impact of metabolic indicators on plantar sudomotor function and to explore the relationships between metabolic and non-metabolic indicators and sudomotor function in a physical examination cohort using Neuropad. Methods: In this cross-sectional study, 481 participants were randomly enrolled. Sudomotor function was evaluated using Neuropad and a handheld color analyzer for both qualitative (visual Neuropad) and quantitative (quantitative Neuropad) analyses. The slope (Slope[1-10]) was used as a quantitative measure of sudomotor function. Additional data included age, BMI (body mass index), FPG (fasting plasma glucose), HbA1c (hemoglobin A1c), blood pressure, lipid levels, and liver and kidney function. Participants were categorized into four blood glucose groups: normoglycemia (FPG <6.1 mmol/L and HbA1c <6%), prediabetes (FPG 6.1-6.9 mmol/L or HbA1c 6.0-6.4%), newly diagnosed diabetes (FPG ≥7.0 mmol/L or HbA1c ≥6.5% with no prior diagnosis, diabetes was diagnosed on the day of the physical examination), and previously diagnosed diabetes. Results: (1) The previously diagnosed diabetes group presented a lower slope than the normoglycemia group (6.96 vs 8.73) and a greater rate of incomplete color change (71.11% vs 49.01%). With increasing FPG and HbA1c levels, the 10-minute slope decreased progressively ( Conclusion: There is a progressive decline in sudomotor function with increasing blood glucose levels in a physical examination cohort, and previously diagnosed diabetes emerges as an independent risk factor for sudomotor dysfunction.
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