ArticleJournal of tissue engineering and regenerative medicine2023
Fluorapatite-Coated Percutaneous Devices Promote Wound Healing and Limit Epithelial Downgrowth at the Skin-Device Interface.
Article in Journal of tissue engineering and regenerative medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Efficacy of Zinc-, Copper-, and Silver-Doped Fluorapatite as Bacteriophobic Surfaces for Percutaneous Osseointegrated Device Applications.ChemNanoMat : chemistry of nanomaterials for energy, biology and more · 2026Article
- Fluorapatite-Coated Percutaneous Osseointegrated Prostheses Limit Epidermal Downgrowth and Promote Periprosthetic Healing in a Weight-Bearing Sheep Model-A Preliminary Study.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Article
- Surface modification strategies to reinforce the soft tissue seal at transmucosal region of dental implants.Bioactive materials · 2024Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A percutaneous osseointegrated device becomes deeply ingrown by endosteal bone and traverses the overlying soft tissues of the residual limb, providing a direct link to the bone-anchored artificial limb. Continuous wound healing around these devices can result in the formation of sinus tracts as "down-growing" epithelial cells are unable to recognize and adhere to the "nonbiological" implant surface. Such sinus tracts provide paths for bacterial colonization and deep infection. In order to limit adverse outcomes and provide a robust seal, it was hypothesized that by coating the titanium surface of the percutaneous post with the mineral component of dental enamel, down-growing epidermal cells might recognize the coating as "biological" and adhere to this nonliving surface. To test this hypothesis, sintered partially and fully fluoridated hydroxyapatite (HA) was chosen as coatings. Using an established surgical protocol, fluorapatite (FA), hydroxyfluorapatite (FHA), HA-coated percutaneous posts, and titanium controls were surgically placed under the dorsal skin in 20 CD hairless rats. The animals were sacrificed at four weeks, and implants and surrounding tissues were harvested and subjected to further analyses. Downgrowth and granulation tissue area data showed statistically significant reductions around the FA-coated devices. Moreover, compared to the control group, the FA- and HA-coated groups showed downregulation of mRNA for EGFr, EGF, and FGF-10. Interestingly, the FA-coated group had upregulation of TGF-
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.