Evidence map›Paper›PMID 40226403›Full record

ArticleJournal of tissue engineering and regenerative medicine2023

Effects of rAAV-Mediated Overexpression of

Wei Liu, Jagadeesh K Venkatesan, Mahnaz Amini, Tamás Oláh, Gertrud Schmitt, Henning Madry, Magali Cucchiarini

Abstract read
In one paragraph

Article in Journal of tissue engineering and regenerative medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wei LiuCenter of Experimental Orthopaedics, Saarland University and Saarland University Medical Center, Homburg/Saar, Germany.ORCID 0000-0001-6099-915X
Jagadeesh K VenkatesanCenter of Experimental Orthopaedics, Saarland University and Saarland University Medical Center, Homburg/Saar, Germany.ORCID 0000-0001-8994-8698
Mahnaz AminiCenter of Experimental Orthopaedics, Saarland University and Saarland University Medical Center, Homburg/Saar, Germany.ORCID 0000-0002-4479-7520
Tamás OláhCenter of Experimental Orthopaedics, Saarland University and Saarland University Medical Center, Homburg/Saar, Germany.ORCID 0000-0002-3834-6272
Gertrud SchmittCenter of Experimental Orthopaedics, Saarland University and Saarland University Medical Center, Homburg/Saar, Germany.
Henning MadryCenter of Experimental Orthopaedics, Saarland University and Saarland University Medical Center, Homburg/Saar, Germany.ORCID 0000-0002-8612-4842
Magali CucchiariniCenter of Experimental Orthopaedics, Saarland University and Saarland University Medical Center, Homburg/Saar, Germany.ORCID 0000-0003-0323-8922

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recombinant adeno-associated virus (rAAV) vectors have a strong potential to promote the healing of traumatic cartilage defects and osteoarthritic lesions upon delivery and overexpression of therapeutic genes from suitable biomaterials that support a controlled release of the candidate constructs. The goal of the present work is to examine whether the administration of chondrogenic rAAV

Indexed as

AlginatesBone Marrow CellsDependovirusGenetic VectorsGene Transfer TechniquesHydrogel, Polyethylene Glycol DimethacrylateHydrogelsMesenchymal Stem CellsSOX9 Transcription FactorTransforming Growth Factor betaCell DifferentiationCell ProliferationChondrogenesisGlucuronic AcidHexuronic AcidsHumansAlginatesGlucuronic AcidHexuronic AcidsHydrogel, Polyethylene Glycol DimethacrylateHydrogelsSOX9 protein, humanSOX9 Transcription FactorTransforming Growth Factor beta

Identifiers

PMID40226403
PMCPMC11919174

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.