Evidence map›Paper›PMID 40226398›Full record

ArticleJournal of tissue engineering and regenerative medicine2023

Endothelial Progenitor Cell Therapy for Fracture Healing: A Dose-Response Study in a Rat Femoral Defect Model.

David J Ramnaraign, Charles Godbout, Kalter Hali, Christian Hegner, Brent D Bates, Sarah Desjardins, Jonathan Peck, Emil H Schemitsch, Aaron Nauth

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of tissue engineering and regenerative medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

David J RamnaraignKeenan Research Centre for Biomedical Science, Unity Health Toronto (St. Michael's Hospital), University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-5790-1091
Charles GodboutKeenan Research Centre for Biomedical Science, Unity Health Toronto (St. Michael's Hospital), University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0003-4805-3454
Kalter HaliKeenan Research Centre for Biomedical Science, Unity Health Toronto (St. Michael's Hospital), University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-6729-8628
Christian HegnerKeenan Research Centre for Biomedical Science, Unity Health Toronto (St. Michael's Hospital), University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0001-8468-8081
Brent D BatesKeenan Research Centre for Biomedical Science, Unity Health Toronto (St. Michael's Hospital), University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0003-3151-7515
Sarah DesjardinsKeenan Research Centre for Biomedical Science, Unity Health Toronto (St. Michael's Hospital), University of Toronto, Toronto, Ontario, Canada.
Jonathan PeckDivision of Orthopaedic Surgery, Department of Surgery, Unity Health Toronto (St. Michael's Hospital), University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-8699-3992
Emil H SchemitschDepartment of Surgery, Western University, London, Ontario, Canada.ORCID 0000-0002-6435-9069
Aaron NauthKeenan Research Centre for Biomedical Science, Unity Health Toronto (St. Michael's Hospital), University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-9186-7747

Funding

CIHR
6 · The paper itself

Abstract

Endothelial progenitor cell (EPC) therapy has been successfully used in orthopaedic preclinical models to heal bone defects. However, no previous studies have investigated the dose-response relationship between EPC therapy and bone healing. This study aimed to assess the effect of different EPC doses on bone healing in a rat model to define an optimal dose. Five-millimeter segmental defects were created in the right femora of Fischer 344 rats, followed by stabilization with a miniplate and screws. Rats were assigned to one of six groups (control, 0.1 M, 0.5 M, 1.0 M, 2.0 M, and 4.0 M;

Indexed as

Endothelial Progenitor CellsFemoral FracturesFemurFracture HealingStem Cell TransplantationAnimalsDisease Models, AnimalMaleRatsRats, Inbred F344X-Ray Microtomography

Identifiers

PMID40226398
PMCPMC11918885

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.