Evidence map›Paper›PMID 40226365›Full record

ArticleCell biomaterials2025

Development of a 3D bioengineered human lung submucosal gland ductal airway model to study mucociliary clearance

Hoyeol Kim, Sujung Yi, Pramodha Liyanage, Shuyang Zhao, Kathryn A Wikenheiser-Brokamp, Lisa McMillin, Yan Xu, Joseph A Kitzmiller, Jeffrey A Whitsett, Anjaparavanda P Naren and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Structural and cellular mechanisms of mucus plugging in the larger airways.Chinese medical journal pulmonary and critical care medicine · 2026
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hoyeol KimDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Sujung YiDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Pramodha LiyanageDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Shuyang ZhaoDivision of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Kathryn A Wikenheiser-BrokampDivision of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Lisa McMillinDivision of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Yan XuDivision of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Joseph A KitzmillerDivision of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Jeffrey A WhitsettDivision of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Anjaparavanda P NarenDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Kyu Shik MunDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

Funding

Pilot and Feasibility ProgramP30DK117467 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Raouf S. Amin, MICHAEL A. HELMRATH · 2018 to 2026
$11.4M
A mechanistic 3D AI-powered map of genetic chILDU01HL175383 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Jichao Chen, Kathryn Ann Wikenheiser-Brokamp · 2024 to 2026
$2.4M
Investigating of the Mechanisms of Action of CFTR Correctors in RescuingDelta F508-CFTRR01HL147351 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI NAREN, ANJAPARAVANDA P · 2020 to 2023
$1.7M
Cellular determinants of responsiveness to mTOR inhibitors in LAMR01HL172914 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI YAN XU, Jane Yu · 2025 to 2026
$1.4M
Multidisciplinary Pulmonary Research Training ProgramT32HL134637 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI NOBLE, PAUL WESLEY · 2017 to 2021
$1.3M
NHLBI NIH HHS R01 HL147351NHLBI NIH HHS R01 HL172914NHLBI NIH HHS T32 HL134637NHLBI NIH HHS U01 HL175383NIDDK NIH HHS P30 DK117467
6 · The paper itself

Abstract

Mucociliary clearance (MCC) is critical in maintaining lung health and preventing respiratory infections. MCC is impaired in people with cystic fibrosis, due to accumulation of thick, sticky mucus resulting from defective cystic fibrosis transmembrane conductance regulator channel function. In this study, we developed a unique 3D lung submucosal gland ductal airway model utilizing primary human submucosal gland epithelial cells, which enables the formation of physiologically relevant architecture of the ductal epithelium including ciliary cells within a 3D bioprinted scaffold. Our observation demonstrates that this model not only enables the fabrication of human lung submucosal gland ductal airway-like structure mimicking

Identifiers

PMID40226365
PMCPMC11984632

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.