Evidence map›Paper›PMID 40226335›Full record

ReviewJournal of orthopaedic translation2025

The effects and mechanisms of electromagnetic fields on bone remodeling: From clinical to laboratory.

Junyu Liu, Weihao Ren, Shenghang Wang, Jiancheng Yang, Hao Zhang, Yuhong Zeng, Dachuan Yin, Peng Shang

Abstract readReview
In one paragraph

Review in Journal of orthopaedic translation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Junyu LiuResearch & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen, 518057, China.
Weihao RenResearch & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen, 518057, China.
Shenghang WangLaw Sau Fai Institute for Advancing Translational Medicine in Bone and Joint Diseases (TMBJ), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China.
Jiancheng YangDepartment of Osteoporosis, Honghui Hospital, Xi'an Jiaotong University, Xi'an, 710054, China.
Hao ZhangDepartment of Spine Surgery, People's Hospital of Longhua, Affiliated Hospital of Southern Medical University, Shenzhen, 518109, China.
Yuhong ZengDepartment of Osteoporosis, Honghui Hospital, Xi'an Jiaotong University, Xi'an, 710054, China.
Dachuan YinSchool of Life Science, Northwestern Polytechnical University, Xi'an, 710072, China.
Peng ShangResearch & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen, 518057, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Electromagnetic fields (EMFs) are physical fields generated by electrically charged objects, and play a vital role in the growth and development of living organisms. Bone is a highly dynamic structure that undergoes a constant remodeling process. From 1962 to 1977, Bassett discovered the piezoelectric effect in bone tissue and found that EMFs accelerated osteogenesis, promoted tibial fracture healing in dogs, and had positive effects in clinical trials. Since then, EMFs have been increasingly studied in bone remodeling disorders as a non-invasive physical therapy. This review summarizes clinical trials and laboratory studies on EMF interventions in bone remodeling disorders over the past few decades, outlining the effects of EMFs on various bone cells and their underlying molecular mechanisms. In addition, we propose issues in current studies and give an outlook on the research and application of EMFs as a non-invasive physical therapy. The translational potential of this article: This article systematically reviews the research ranging from biological and physical mechanisms to medical applications of EMFs on bone remodeling and related diseases, identifies key challenges in future basic research, and proposes new strategies for developing novel medical equipment and advancing clinical applications in this field. These insights contribute to the advancement of non-invasive physical therapies in orthopedics.

Indexed as

Bone remodelingElectromagnetic fieldsFractureOsteoporosisPhysical therapy

Identifiers

PMID40226335
PMCPMC11986540

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.