Evidence map›Paper›PMID 40226311›Full record

ArticleHuman mutation2025

Gene Mutation Characteristics and Prognostic Significance in Acute Myeloid Leukemia Patients From Northeast China.

Yiyang Shen, Shuang Fu, Xuan Liu, Jianing Liu, Yu Fu, Yue Zhao, Xinxin Wang, Xujian Jiang, Jihong Zhang

Abstract read
In one paragraph

Article in Human mutation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yiyang ShenHematology Laboratory, Shengjing Hospital of China Medical University, Shenyang, China.ORCID 0009-0007-0188-1806
Shuang FuHematology Laboratory, Shengjing Hospital of China Medical University, Shenyang, China.ORCID 0000-0002-9005-5982
Xuan LiuHematology Laboratory, Shengjing Hospital of China Medical University, Shenyang, China.ORCID 0009-0008-9214-4269
Jianing LiuHematology Laboratory, Shengjing Hospital of China Medical University, Shenyang, China.ORCID 0009-0006-1093-735X
Yu FuHematology Laboratory, Shengjing Hospital of China Medical University, Shenyang, China.ORCID 0000-0002-7989-8065
Yue ZhaoHematology Laboratory, Shengjing Hospital of China Medical University, Shenyang, China.ORCID 0000-0002-7968-9773
Xinxin WangHematology Laboratory, Shengjing Hospital of China Medical University, Shenyang, China.ORCID 0000-0002-1986-0217
Xujian JiangHematology Laboratory, Shengjing Hospital of China Medical University, Shenyang, China.ORCID 0000-0002-5080-7158
Jihong ZhangHematology Laboratory, Shengjing Hospital of China Medical University, Shenyang, China.ORCID 0000-0002-5921-2417

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A great part of studies on the correlation between gene mutations and prognosis in acute myeloid leukemia (AML) patients are based on Western populations. To profile the genomic landscape of AML patients in Northeast China, we retrospectively analyzed the clinical data of 377 newly diagnosed AML patients in Shengjing Hospital of China Medical University from 2016 to 2022 and compared them with data from other populations with different genetic backgrounds. The mutation status of

Indexed as

Leukemia, Myeloid, AcuteMutationAdolescentAdultAgedAged, 80 and overCCAAT-Enhancer-Binding ProteinsChinaDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3AFemaleHigh-Throughput Nucleotide SequencingHumansMaleMiddle AgedNucleophosminCCAAT-Enhancer-Binding ProteinsCEBPA protein, humanDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADNMT3A protein, humanNPM1 protein, humanNucleophosminacute myeloid leukemiagene mutationsnext-generation sequencing

Identifiers

PMID40226311
PMCPMC11918257

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.