ArticleIndian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India2025
Cochlear Synaptopathy in Full-Term Neonates: A Case-Control Study of NICU Hospitalization Impact.
Article in Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aims: Cochlear synaptopathy, or hidden hearing loss, involves synaptic loss between inner hair cells and auditory nerve fibers. While linked to aging and excessive noise exposure in adults, its impact on neonates remains unclear. This study compared cochlear synaptopathy in full-term neonates hospitalized in the neonatal intensive care unit (NICU) versus healthy controls. Methods: Sixty full-term neonates-30 hospitalized in the neonatal intensive care unit (NICU) and 30 healthy controls-were enrolled. Inclusion criteria comprised gestational age ≥ 37 weeks, chronological age < 1-month, normal auditory brainstem response (ABR) thresholds (≤ 25 dB nHL), transient evoked otoacoustic emissions, and tympanometry. ABR wave I and V amplitudes, wave I/V ratio, growth functions, acoustic reflex thresholds (ART), and adaptation tests (rapid-rate ABR) were analyzed. Results: No significant differences emerged between NICU-hospitalized and control neonates in ABR wave I/V amplitudes (wave I: 0.05-0.15 µV vs. 0.06-0.11 µV; wave V: 0.12-0.21 µV vs. 0.14-0.20 µV), I/V ratio (0.57-0.75 vs. 0.54-0.67), ART (80.35-73.14 dB HL vs. 78.44-71.59 dB HL), or adaptation latencies (7.60 ms vs. 7.56 ms). Conclusion: The results suggest that NICU hospitalization does not significantly increase the risk of cochlear synaptopathy in full-term neonates, even when evaluating synaptic integrity using ABR wave I/V ratios, a biomarker for hidden hearing loss, despite normal hearing thresholds.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.