Evidence map›Paper›PMID 40226230›Full record

Observational studyInternational journal of chronic obstructive pulmonary disease2025

Characteristics of Patients Receiving Budesonide/Glycopyrronium/Formoterol for Chronic Obstructive Pulmonary Disease in Spain: The AURA Study.

Myriam Calle Rubio, Juan Antonio Trigueros Carrero, Paula Chaparro Briones, Luciano Escudero Herrera, Michael Pollack, Ignacio Hernández Subirá, Joaquín Sánchez-Covisa

Abstract readObservational Study
In one paragraph

Observational study in International journal of chronic obstructive pulmonary disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Observational
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Myriam Calle RubioPneumology Service, H. Clínico San Carlos. Institute for Health Research (IdISSC), Department of Medicine, Complutense University, CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain.ORCID 0000-0002-3890-2742
Juan Antonio Trigueros CarreroBuenavista Primary Care Center, Toledo, Spain.ORCID 0000-0001-9180-2268
Paula Chaparro BrionesAstraZeneca Farmacéutica Spain, Madrid, Spain.ORCID 0009-0007-4551-2826
Luciano Escudero HerreraAstraZeneca Farmacéutica Spain, Madrid, Spain.
Michael PollackAstraZeneca, LP. BioPharmaceuticals Medical, Wilmington, DE, USA.ORCID 0000-0001-7351-3059
Ignacio Hernández SubiráAtrys Health SA, HEOR, Madrid, Spain.
Joaquín Sánchez-CovisaAstraZeneca Farmacéutica Spain, Madrid, Spain.ORCID 0000-0002-6407-3669

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Single-inhaler triple therapy with budesonide/glycopyrronium/formoterol fumarate (BGF; Trixeo Aerosphere Methods: Electronic medical records in the Spanish Healthcare System anonymized, integrated BIG-PAC Results: Patients (N=482) had a mean (standard deviation, SD) age of 71.5 (10.0) years, mean BMI of 29.6 (6.2) kg/m Conclusion: Single-inhaler BGF triple therapy was initiated mostly as an escalation from dual maintenance therapy, with many switching from triple therapy, in patients with a high burden of disease, as demonstrated by their frequent exacerbation profile, advanced COPD severity (moderate to very severe obstruction) and the high frequency of several comorbidities, including cardiovascular diseases.

Indexed as

Adrenergic beta-2 Receptor AgonistsBronchodilator AgentsBudesonideFormoterol FumarateGlycopyrrolateLungMuscarinic AntagonistsPulmonary Disease, Chronic ObstructiveAdministration, InhalationAgedAged, 80 and overDrug CombinationsDrug Therapy, CombinationFemaleHumansMaleAdrenergic beta-2 Receptor AgonistsBronchodilator AgentsBudesonideDrug CombinationsFormoterol FumarateGlycopyrrolateMuscarinic Antagonistsbudesonide/glycopyrronium/formoterolchronic obstructive pulmonary diseaseexacerbationsreal-world datasingle-inhaler triple therapy

Identifiers

PMID40226230
PMCPMC11994078

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.