Evidence map›Paper›PMID 40226221›Full record

ArticleCase reports in hepatology2025

Unmasking Hepatitis A: A Case Study of Atypical Presentation in a Returning Traveler From Egypt.

Emmanuel Edwar Siddig, Claude M Muvunyi, Ayman Ahmed

Abstract readCase Reports
In one paragraph

Article in Case reports in hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Emmanuel Edwar SiddigFaculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan.ORCID https://orcid.org/0000-0001-6314-7374
Claude M MuvunyiRwanda Biomedical Centre, Kigali, Rwanda.ORCID https://orcid.org/0000-0003-4180-442X
Ayman AhmedRwanda Biomedical Centre, Kigali, Rwanda.ORCID https://orcid.org/0000-0002-9516-9508

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatitis, characterized by inflammation of the liver, arises from various infectious and noninfectious causes, with viral hepatitis being caused by a diverse group of viruses including hepatitis A, B, C, D, and E. Infection with the Hepatitis A virus (HAV) can result in liver inflammation and damage, primarily spread through fecal-oral contamination. Clinical symptoms often overlap with other infections, complicating diagnosis in returning travelers from endemic regions. This case study focuses on a 46-year-old Sudanese housewife who presented with symptoms of fever, chills, headache, and muscle aches, along with a high temperature of 103.5°F, following a recent visit to Egypt. The initial assessment showed hemodynamic stability and abnormal liver function tests. This raise suspicion about the potential involvement of several infections including malaria, hepatitis, arboviral diseases such as Chikungunya, Yellow, and dengue fevers. Further investigations revealed acute hepatitis A infection confirmed through positive serology. Notably, the patient displayed atypical features such as atypical lymphocytosis, splenomegaly, and mild anemia. This case emphasizes the significance of essentially considering a wide range of diseases among travelers including hepatitis A among people coming from highly endemic areas such as Egypt, even when the patient is not manifested with the typical clinical presentation of specific disease. Particular attention is needed for epidemic-prone infections like hepatitis A.

Indexed as

atypical lymphocytesatypical presentationdiagnostic challengehepatitis Atravel medicine

Identifiers

PMID40226221
PMCPMC11991758

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.