Evidence map›Paper›PMID 40226211›Full record

ArticleDrug and alcohol dependence reports2025

Influence of SSRI and SNRI co-prescription on benzodiazepine prescription trajectories.

Kerry L Kinney, Eliseu da Cruz Moreira-Junior, Laís F Berro, Matthew C Morris, James K Rowlett

Abstract read
In one paragraph

Article in Drug and alcohol dependence reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kerry L KinneyOsher Center for Integrative Health, Department of Physical Medicine & Rehabilitation, Vanderbilt University Medical Center, 3401 West End Ave, Nashville, TN 37203, USA.
Eliseu da Cruz Moreira-JuniorDepartment of Psychiatry and Human Behavior, University of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216, USA.
Laís F BerroDepartment of Psychiatry and Human Behavior, University of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216, USA.
Matthew C MorrisDepartment of Psychiatry and Human Behavior, University of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216, USA.
James K RowlettDepartment of Psychiatry and Human Behavior, University of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216, USA.

Funding

ANXIOLYTIC EFFECTS AND ABUSE OF BZ RECEPTOR LIGANDSR01DA011792 · NIDA · UNIVERSITY OF MISSISSIPPI MED CTR · PI ROWLETT, JAMES K · 1998 to 2024
$7.8M
LIFE-SPAN DEVELOPMENT OF NORMAL AND ABNORMAL BEHAVIORT32MH018921 · NIMH · VANDERBILT UNIVERSITY · PI HUMPHREYS, KATHRYN LEIGH · 1989 to 2024
$6.7M
Tolerance and Physical Dependence after Chronic Benzodiazepine TreatmentR01DA043204 · NIDA · UNIVERSITY OF MISSISSIPPI MED CTR · PI JAMES K ROWLETT · 2017 to 2026
$4.3M
Mechanisms of transition from acute to chronic pain in Non-Hispanic Black and White injury patientsR01MD016838 · NIMHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Matthew C. Morris · 2022 to 2026
$3.5M
Role of orexin receptors in the abuse- and sleep-related effects of methamphetamineR00DA049886 · NIDA · UNIVERSITY OF MISSISSIPPI MED CTR · PI BERRO, LAIS F · 2022 to 2024
$747k
Delineating Sources of Racial, Ethnic, and Socioeconomic Differences in the Diagnosis of Generalized Anxiety DisorderK01MD020122 · NIMHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Kerry Kinney · 2024 to 2026
$197k
NIDA NIH HHS R00 DA049886NIDA NIH HHS R01 DA011792NIDA NIH HHS R01 DA043204NIMHD NIH HHS K01 MD020122NIMHD NIH HHS R01 MD016838NIMH NIH HHS T32 MH018921
6 · The paper itself

Abstract

Purpose: This study examined whether co-prescription of selective serotonin reuptake inhibitors (SSRIs) or serotonin or norepinephrine reuptake inhibitors (SNRI)s with benzodiazepines is associated with differences in benzodiazepine prescriptions both within individual patients over time and between patients. Methods: We analyzed deidentified electronic health records of patients prescribed a benzodiazepine between 2020 and 2022 ( Results: Individuals co-prescribed an SSRI ( Conclusions: Individuals who are co-prescribed an SSRI/SNRI may be vulnerable to longer treatment durations and higher prescribed doses of benzodiazepines, raising concerns about risk for dependence among individuals receiving combined benzodiazepine and SSRI/SNRI treatment.

Indexed as

BenzodiazepinePrescribing practicesPrescriptionSelective serotonin reuptake inhibitorSerotonin and norepinephrine reuptake inhibitor

Identifiers

PMID40226211
PMCPMC11986241

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.