Evidence map›Paper›PMID 40226137›Full record

ArticleIJTLD open2025

Low preventive treatment initiation and completion among young children contacts of active TB in Tbilisi, Georgia.

E Kokhreidze, R R Kempker, N Tukvadze, M C Schechter, Z Avaliani, H M Blumberg, M Butsashvili, N Lomtadze

Abstract read
In one paragraph

Article in IJTLD open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

E KokhreidzeEuropean University, Tbilisi, Georgia.
R R KempkerDivision of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
N TukvadzeNational Center for Tuberculosis and Lung Diseases, Tbilisi, Georgia.
M C SchechterDivision of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Z AvalianiEuropean University, Tbilisi, Georgia.
H M BlumbergDivision of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
M ButsashviliUniversity of Georgia, Tbilisi, Georgia.
N LomtadzeNational Center for Tuberculosis and Lung Diseases, Tbilisi, Georgia.

Funding

Emory/Georgia TB Research Advancement Center (TRAC)P30AI168386 · NIAID · EMORY UNIVERSITY · PI Neel Rajnikant Gandhi · 2022 to 2026
$5.8M
Emory-Georgia TB Research Training ProgramD43TW007124 · FIC · EMORY UNIVERSITY · PI HENRY M BLUMBERG, Nestani Tukvadze · 2004 to 2026
$4.6M
FIC NIH HHS D43 TW007124NIAID NIH HHS P30 AI168386
6 · The paper itself

Abstract

backgroundWithin the Georgian National Tuberculosis Program (NTP), TB preventive treatment (TPT) is recommended for all child TB contacts ≤5 years. To assess adherence to this guidance, we evaluated the care cascade for the treatment of latent TB infection among children ≤5 years at the National Center for Tuberculosis and Lung Disease (NCTLD).

methodsWe performed a cohort study among children ≤5 years evaluated at NCTLD during 2012-2014 as a contact of active pulmonary TB people. We recorded how many patients were recommended to start isoniazid preventive therapy (IPT) and how many initiated and completed treatment.

resultsAmong 172 contacts of active TB people who visited the NCTLD between 2012 and 2014, 134 (74%) were contacts to drug-susceptible TB index cases. Among children recommended to start IPT (

conclusionsOur findings highlight low rates of LTBI treatment recommendation, TPT initiation and completion among young children who were TB contacts in Georgia, highlighting the need for improved monitoring and enhanced treatment programs and regimens.

Indexed as

child contact investigationisoniazidlatent tuberculosis infectionpreventive treatment

Identifiers

PMID40226137
PMCPMC11984523

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.