Evidence map›Paper›PMID 40226114›Full record

ArticleJHEP reports : innovation in hepatology2025

Protective value of ischemia-free liver transplantation on post-transplant acute kidney injury.

Qiang Zhao, Jinbo Huang, Meiting Qin, Yunhua Tang, Zhiying Liu, Yefu Li, Zhiyong Guo, Jia Dan, Yu Nie, Xiaoshun He

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JHEP reports : innovation in hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Qiang ZhaoOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Jinbo HuangOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Meiting QinOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Yunhua TangOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Zhiying LiuZhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Yefu LiOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Zhiyong GuoOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Jia DanOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Yu NieGeneral Surgery Center, Department of Hepatobiliary Surgery II, Research Center for Artificial Organ and Tissue Engineering, Guangzhou Clinical Research and Transformation Center for Artificial Liver, Institute of Regenerative Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Xiaoshun HeOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background & Aims: Ischemia-free liver transplantation (IFLT) completely avoids ischemia-reperfusion injury (IRI), thus potentially reducing acute kidney injury (AKI) after liver transplantation (LT). Therefore, this study investigated whether IFLT has a protective effect against AKI after LT. Methods: In total, 862 patients who had undergone LT between 2017 to 2022 were divided into an ischemia-free liver transplantation group (IFLT group) and conventional liver transplantation group (CLT group) based on the surgical methods used. Propensity score matching (PSM) was used for post hoc randomization in the 1:1 matching between the groups. Post-transplant kidney function, graft function, and patient survival were compared between the groups. Multivariate logistic regression analysis was used to identify the risk factors of AKI after LT. Results: Overall, 745 out of 862 patients were finally enrolled, of whom 98 underwent IFLT. PSM created 94 pairs of patients. IFLT resulted in a significant reduction in Stage-3 AKI (3.2% Conclusions: IFLT significantly reduces the incidence of post-transplant SCKI, Stage-3 AKI, and RRT. Importantly, this protective effect is also present in patients receiving ECD livers. Impact and implications: Ischemia-free liver transplantation significantly reduces the incidence of severe acute kidney injury, Stage-3 acute kidney injury and renal replacement therapy after liver transplantation. Importantly, this protective effect is also present in patients receiving extended criteria donation livers. Clinical trial number: ChiCTR2400081755.

Indexed as

Acute kidney injuryExtended criteria donorIschemia-free liver transplantationPropensity score matching

Identifiers

PMID40226114
PMCPMC11986513

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.