ArticleTranslational andrology and urology2025
Significance of split-dose cisplatin-based neoadjuvant chemotherapy followed by robotic-assisted radical cystectomy for muscle invasive bladder cancer.
Article in Translational andrology and urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparative efficacy and safety of carboplatin-based versus cisplatin-based chemotherapy in muscle-invasive and advanced bladder cancer: A systematic review and meta-analysis.European journal of clinical pharmacology · 2026Pooled it
- CarboxymethylatedFood science & nutrition · 2026Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Although cisplatin is essential for neoadjuvant chemotherapy (NAC) in patients with muscle-invasive bladder cancer (MIBC), good renal function is a prerequisite for those patients receiving NAC. However, patients with normal renal function may experience nephrotoxicity after cisplatin administration. We investigated the safety and efficacy of a split-dose regimen of gemcitabine and cisplatin (split-dose GC) in MIBC patients with normal renal function. Methods: This retrospective study included 45 patients with MIBC who received standard GC, split-dose GC, or gemcitabine and carboplatin (GCarbo) as a NAC and subsequently underwent robot-assisted radical cystectomy. The efficacy and safety of two cycles split-dose GC were compared with those of other regimens. Results: Among the 45 patients with MIBC, 14 received standard GC, 14 received split-dose GC, and 17 received GCarbo. Pathological complete response rates were 28.6%, 21.4%, and 29.4% for surgical specimens obtained post-treatment with standard GC, split-dose GC, and GCarbo, respectively (P=0.86). Renal function after NAC was significantly lower in the standard- and split-dose GC groups than in the GCarbo group (P<0.001). Conclusions: Although the split-dose GC regimen showed a significant reduction compared to pre-treatment renal function, the pathological response rate and incidence of adverse events were similar to those of the other two regimens.
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