ArticleAmerican journal of translational research2025
Correlation between ultrasound characteristics of thyroid microcarcinoma and levels of thyroid-stimulating hormone and vascular endothelial growth factor.
Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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7 authors.
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Abstract
objectivesTo investigate the role of thyroid-stimulating hormone (TSH) and vascular endothelial growth factor (VEGF) in the ultrasound characteristics of thyroid microcarcinoma (TMC).
methodsIn this retrospective cohort study, data from 223 TMC patients (January 2018 - January 2023) were analyzed. Patients were grouped based on their baseline serum TSH and VEGF levels. Thyroid ultrasound images were evaluated for morphological features associated with TSH and VEGF concentrations.
resultsA significant correlation was found between elevated TSH levels and increased nodule diameter (rho = 0.193, P = 0.004), clearer margins (rho = 0.196, P = 0.003), and microcalcifications (rho = 0.256, P < 0.001). Capsule invasion showed a negative correlation with TSH (rho = -0.180, P = 0.007). Similar associations were observed with higher VEGF levels, which correlated positively with larger nodule size (rho = 0.189, P = 0.005), clearer margins (rho = 0.186, P = 0.005), and microcalcifications (rho = 0.265, P < 0.001), but negatively with capsule invasion (rho = -0.169, P = 0.012).
conclusionThis study supports the hypothesis that elevated TSH and VEGF levels are associated with characteristic ultrasound features in TMC, which may serve as potential biomarkers for more accurate risk stratification.
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