ArticleAmerican journal of translational research2025
Altered uterine artery protein signature and function following E-cigarette exposure in pregnancy.
Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Uterine artery transcriptomic signatures of e-cigarette aerosol exposure in pregnancy.Reproductive toxicology (Elmsford, N.Y.) · 2026Article
- Vaping in Pregnancy: Unraveling Molecular Drivers of Preeclampsia and Fetal Growth Restriction.International journal of molecular sciences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
objectiveOver the past decade e-cigarette (e-cig) usage has become a growing public health concern, especially during pregnancy as many perceive e-cigs as a safer alternative to combustible cigarettes. Although human and animal models exhibit altered uterine artery Doppler velocimetry and waveform abnormalities following traditional smoking and buccal nicotine exposure, the effects of e-cig aerosols on pregnancy are incompletely researched and understood. We hypothesized that an altered uterine artery proteomic signature, accompanied by functional deficits, will be caused by e-cig vaping during pregnancy.
methodsIn a validated timed pregnant Sprague-Dawley rat model system, a custom-engineered vaping system comprising a commercial atomizer and vape unit was utilized to generate and deliver e-cig aerosols that mimic the aerosols produced by commercial e-cigs, once daily, to pregnant dams.
resultsMean fetal weight, crown-rump length, and placental weight were significantly lower in the E-Cig group than those in the pair-fed Control group. Mass spectrometry followed by proteomic analysis detected a total of 2129 proteins; 36 significantly altered proteins were mostly related to immune system and vasodilation. Principal component analysis validated the protein signature. The uterine arteries of e-cig exposed rats demonstrated impaired concentration-dependent acetylcholine-induced uterine artery relaxation. Supplementation of N(ω)-nitro-L-arginine methyl ester (L-NAME) confirmed a role for the nitric oxide (NO) system. Immunofluorescence validated the localization to the uterine artery endothelium and the decreased levels of vasodilatory excitatory P-Ser
conclusionsIdentifying the pathway(s) involved in the pathogenesis of uterine artery dysfunction creates a potential for pinpointing antagonistic and/or reversal medications, thereby preventing or reducing e-cigarette mediated uteroplacental dysfunction and fetal growth restriction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.