ArticleAmerican journal of translational research2025
Serum IL-18R1 and its effect on immune cell infiltration in asthma.
Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Genetically prioritized plasma proteins in intracerebral hemorrhage identified by Mendelian randomization with functional evidence of neuronal vulnerability.American journal of translational research · 2026Article
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10 authors.
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Abstract
objectiveAsthma is a common chronic respiratory disease, affecting 5-10% of the global population. Despite its widespread impact, underdiagnosis remains a significant concern. This study aimed to explore the diagnostic potential of interleukin 18 receptor 1 (IL-18R1) and its relationship to immune cell infiltration in asthma.
methodsWe retrospectively collected clinical and laboratory data of all participants. The expression of serum IL-18R1 in patients with asthma and healthy controls was quantified using enzyme linked immunosorbent assay (ELISA). The associations of IL-18R1 with clinical laboratory indicators and the diagnostic efficacy of IL-18R1 for asthma were assessed. Bioinformatic analysis was used to explore the biological function of IL-18R1 in asthma.
resultsPeripheral blood white blood cells (WBC), neutrophils (NE), eosinophils (EO) and serum IL-18R1 were significantly elevated in patients with asthma compared to heathy controls. Patients with high IL-18R1 also had increased blood lymphocytes. The expression of IL-18R1 was associated with diverse immune cell infiltration and inflammatory pathways. Mendelian randomization (MR) analysis revealed a positive relationship between IL-18R1 and asthma. The area under the receiver operating characteristic (ROC) curve of the combination of IL-18R1 with WBC was 0.884, with a sensitivity and specificity of 84.8% and 81.8%.
conclusionElevated expression of IL-18R1 is linked to the infiltration of various immune cells and the activation of inflammatory pathways. The combination of IL-18R1 and WBC may be a biomarker with high diagnostic accuracy for asthma.
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