Evidence map›Paper›PMID 40225996›Full record

ArticleAmerican journal of translational research2025

Bing Jiang, Wenxin Gao, Haoyue Hu, Nianchao Zhou, Tiantian Wu, Gaigai Wang, Cong Shen, Xiaoyan Huang, Yibo Wu

Abstract read
In one paragraph

Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. WSB1 is dispensable for mouse spermatogenesis and male fertility.American journal of translational research · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bing JiangHuman Reproductive and Genetic Center, Affiliated Hospital of Jiangnan University Wuxi 214062, Jiangsu, China.
Wenxin GaoState Key Laboratory of Reproductive Medicine and Offspring Health, Department of Histology and Embryology, School of Basic Medical Sciences, Nanjing Medical University Nanjing 211166, Jiangsu, China.
Haoyue HuHuman Reproductive and Genetic Center, Affiliated Hospital of Jiangnan University Wuxi 214062, Jiangsu, China.
Nianchao ZhouHuman Reproductive and Genetic Center, Affiliated Hospital of Jiangnan University Wuxi 214062, Jiangsu, China.
Tiantian WuState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproduction and Genetics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University Suzhou 215002, Jiangsu, China.
Gaigai WangState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproduction and Genetics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University Suzhou 215002, Jiangsu, China.
Cong ShenState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproduction and Genetics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University Suzhou 215002, Jiangsu, China.
Xiaoyan HuangState Key Laboratory of Reproductive Medicine and Offspring Health, Department of Histology and Embryology, School of Basic Medical Sciences, Nanjing Medical University Nanjing 211166, Jiangsu, China.
Yibo WuHuman Reproductive and Genetic Center, Affiliated Hospital of Jiangnan University Wuxi 214062, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSpermatogenesis, the process by which male germ cells develop into mature spermatozoa, is a complex and highly regulated phenomenon crucial for male fertility. Various molecular pathways, including ubiquitination, play critical roles in this process. Ubiquitination regulates multiple stages of spermatogenesis by controlling cell remodeling and protein metabolism. SplA/ryanodine receptor domain and SOCS box containing 3 (SPSB3), a SOCS box protein, interacts with ElonginC/B and recruits Cullin5 to form the ECS E3 ligase complex, which is involved in cell development, proliferation, stress response, and apoptosis. However, the specific role of SPSB3 in spermatogenesis and male reproduction remains poorly understood.

methodsThe distribution and expression of

resultsOur findings indicate that

conclusionThis is the first functional study of

Indexed as

male fertilityspermatogenesisSpsb3testis

Identifiers

PMID40225996
PMCPMC11982890

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.