ReviewAmerican journal of translational research2025
Preventive effects of perioperative drug injection on postoperative delirium after hip fracture surgery: a systematic review and meta-analysis.
Review in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo systematically evaluate the efficacy of perioperative drug injection in preventing postoperative delirium (POD) following hip fracture (HF) surgeries.
methodsThis research scheme was published on the PROSPERO platform (registration number: CRD42024602190). Databases searched included PubMed, Web of Science, Embase, and Cochrane. The search deadline was July 2024. Statistical analyses were conducted using StataSE15.0 software. Paired analysis and network meta-analysis were performed in R Studio, with included drugs ranked using the cumulative ranking probability plot area (SUCRA) for each outcome measure. The incidence, severity, and duration of delirium were analyzed using risk ratios (RR), weighted mean differences (WMD), and their corresponding 95% confidence intervals (CI).
resultsThis meta-analysis included 13 studies: 9 RCTs and 4 cohort studies involving 2,291 patients with HF. The results indicated a significant reduction in the incidence of POD among patients who received perioperative drug injections, with a combined RR of 0.56 [95% CI (0.47, 0.67), P < 0.001]. There was also a significant reduction in the severity of delirium, with a combined WMD of -2.78 [95% CI (-4.38, -1.19), P = 0.01]. However, there were no significant differences in the duration of delirium or the incidence of adverse events, with combined values of [WMD = -1.81, 95% CI (-3.89, 0.27), P = 0.088] and [RR = 1.34, 95% CI (0.78, 2.32), P = 0.294], respectively. Network meta-analysis identified morphine as the most effective drug for preventing delirium, with a SUCRA value of 19.1%.
conclusionIn patients undergoing surgery for HF, perioperative drug injections significantly reduce the incidence and severity of postoperative delirium, with intrathecal morphine being the most effective option for prevention. These findings provide valuable insights for managing postoperative delirium prevention in HF patients. Further high-quality randomized controlled studies are needed to validate these results.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.