ArticleAmerican journal of translational research2025
circRNA_0005927 inhibits gastric cancer metastasis by downregulating the miR-570-3p/FOXO3 axis.
Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Exosomal circ0000549 promotes MNNG‑induced gastric cancer through miR‑15b‑5p/KIF1B.International journal of molecular medicine · 2026Article
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5 authors.
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Abstract
objectiveThis study aimed to explore the effects of circ_0005927 on proliferation, invasion, and epithelial-mesenchymal transformation (EMT) in gastric cancer (GC) cells through its negative modulation of the miR-570-3p/FOXO3 axis.
methodsThe expression levels of circ_0005927, miR-570-3p, and FOXO3 in GC tissues and cells were measured using quantitative reverse transcription polymerase chain reaction (qRT-PCR). Proliferation, colony formation, invasion, and EMT were assessed by MTT assay, colony formation assay, Transwell assay and western blotting, respectively. RNase R digestion and nuclear-cytoplasmic fractionation were performed to evaluate the properties of circ_0005927. A dual luciferase reporter assay was conducted to verify the interaction between circ_0005927, miR-570-3p, and FOXO3.
resultsCirc_0005927 and FOXO3 expression were significantly lower in GC tissues compared to adjacent normal tissues, while miR-570-3p was upregulated (all P<0.05). Low circ_0005927 and high miR-570-3p expression were associated with poor prognosis in GC patients (both P<0.05). In GC cells, circ_0005927 mediated FOXO3 expression by binding to miR-570-3p (P<0.05). Overexpression of circ_0005927 inhibited GC cell proliferation, colony formation, invasion and EMT, whereas overexpression of miR-570-3p or FOXO3 knockdown partially reversed these effects (all P<0.05).
conclusionCirc_0005927 inhibits the proliferation, colony formation, invasion and EMT of GC cells through the upregulation of FOXO3, facilitated by the sequestration of miR-570-3p. Targeting the circ_0005927/miR-570-3p/FOXO3 axis may offer a promising therapeutic approach for GC.
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