Evidence map›Paper›PMID 40225914›Full record

ArticleHuman mutation2024

Genome Sequencing of Idiopathic Speech Delay.

Else Eising, Arianna Vino, Heather L Mabie, Thomas F Campbell, Lawrence D Shriberg, Simon E Fisher

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human mutation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Childhood motor speech disorders: who to prioritise for genetic testing.European journal of human genetics : EJHG · 2026
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Else EisingLanguage and Genetics Department, Max Planck Institute for Psycholinguistics, 6525 XD Nijmegen, Netherlands.ORCID 0000-0001-9819-1260
Arianna VinoLanguage and Genetics Department, Max Planck Institute for Psycholinguistics, 6525 XD Nijmegen, Netherlands.
Heather L MabieWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA.
Thomas F CampbellSchool of Behavioral and Brain Sciences, Callier Center for Communication Disorders, University of Texas at Dallas, Dallas, USA.
Lawrence D ShribergWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA.
Simon E FisherLanguage and Genetics Department, Max Planck Institute for Psycholinguistics, 6525 XD Nijmegen, Netherlands.ORCID 0000-0002-3132-1996

Funding

STUDIES IN DEVELOPMENTAL PHONOLOGICAL DISORDERSR01DC000496 · NIDCD · UNIVERSITY OF WISCONSIN-MADISON · PI SHRIBERG, LAWRENCE D · 1988 to 2017
$9.9M
Waisman Intellectual and Developmental Disabilities Research Center Down Syndrome RegistryU54HD090256 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI POLLAK, SETH D · 2016 to 2020
$6.0M
NICHD NIH HHS U54 HD090256NIDCD NIH HHS R01 DC000496
6 · The paper itself

Abstract

Genetic investigations of people with speech and language disorders can provide windows into key aspects of human biology. Most genomic research into impaired speech development has so far focused on childhood apraxia of speech (CAS), a rare neurodevelopmental disorder characterized by difficulties with coordinating rapid fine motor sequences that underlie proficient speech. In 2001, pathogenic variants of

Indexed as

Language Development DisordersChildChild, PreschoolFemaleForkhead Transcription FactorsGenetic Predisposition to DiseaseHumansMaleWhole Genome SequencingForkhead Transcription FactorsFOXP2 protein, human

Identifiers

PMID40225914
PMCPMC11918988

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.