Evidence map›Paper›PMID 40225859›Full record

ArticleInternational journal of medical sciences2025

Indoxyl sulfate is associated with cognitive impairment in ESRD patients by activating the extrinsic apoptosis in the neuronal cells during differentiating process.

Chih-Chuan Hsieh, Kuo-Cheng Lu, Chuen-Lin Huang, Jiun-Jie Wang, Ting-Yin Yeh, Shyh-Min Lin, Ya-Ling Chung, Yi-Chou Hou, Yuahn-Sieh Huang

Abstract read
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In one paragraph

Article in International journal of medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chih-Chuan HsiehDepartment of Surgery, Zuoying Armed Forces General Hospital, Kaohsiung, Taiwan.
Kuo-Cheng LuDivision of Nephrology, Department of Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan; Division of Nephrology, Department of Medicine, Fu-Jen Catholic University Hospital, School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan.
Chuen-Lin HuangDepartment of Medical Research, Cardinal Tien Hospital, New Taipei City, Taiwan.
Jiun-Jie WangHealthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan.
Ting-Yin YehGraduate Institute of Life Sciences, National Defense Medical Center, Taipei City, Taiwan.
Shyh-Min LinDivision of Radiology, Department of Medicine, Cardinal Tien Hospital, New Taipei City, Taiwan.
Ya-Ling ChungDepartment of Medical Laboratory, Cardinal-Tien Hospital, New Taipei City, Taiwan.
Yi-Chou HouDivision of Nephrology, Department of Internal Medicine, Cardinal Tien Hospital, School of Medicine, Fu Jen Catholic University, New Taipei City, New Taipei City, Taiwan.
Yuahn-Sieh HuangDepartment of Biology and Anatomy, National Defense Medical Center, Taipei City 11490, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cognitive DysfunctionIndicanKidney Failure, ChronicAdultAgedAnimalsApoptosisCell DifferentiationCell Line, TumorDisease Models, AnimalFemaleHumansMaleMiceMice, Inbred C57BLMiddle AgedIndicancholine acetyltransferaseCognitive impairmentdifferentiatingdifferentiationEnd stage renal diseaseextrinsic apoptosisindoxyl sulfatememory lossStem cell.

Identifiers

PMID40225859
PMCPMC11983300

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.