Evidence map›Paper›PMID 40225815›Full record

ArticleCase reports in oncological medicine2025

Remarkable Antitumor Effects and Serious Multiple Immune-Related Adverse Events in Malignant Pleural Mesothelioma: Two Case Reports.

Koharu Harada, Hidehiro Irie, Akifumi Mitsuishi, Takahiro Fukui, Nao Takada, Ryosuke Nagaoka, Yohei Funatsu, Hidefumi Koh

Abstract readCase Reports
In one paragraph

Article in Case reports in oncological medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Koharu HaradaDivision of Pulmonary Medicine, Department of Internal Medicine, Tachikawa Hospital, Tachikawa, Tokyo, Japan.
Hidehiro IrieDivision of Pulmonary Medicine, Department of Internal Medicine, Tachikawa Hospital, Tachikawa, Tokyo, Japan.ORCID https://orcid.org/0000-0001-7973-1006
Akifumi MitsuishiDivision of Pulmonary Medicine, Department of Internal Medicine, Tachikawa Hospital, Tachikawa, Tokyo, Japan.
Takahiro FukuiDivision of Pulmonary Medicine, Department of Internal Medicine, Tachikawa Hospital, Tachikawa, Tokyo, Japan.
Nao TakadaDivision of Pulmonary Medicine, Department of Internal Medicine, Tachikawa Hospital, Tachikawa, Tokyo, Japan.
Ryosuke NagaokaDivision of Pulmonary Medicine, Department of Internal Medicine, Tachikawa Hospital, Tachikawa, Tokyo, Japan.
Yohei FunatsuDivision of Pulmonary Medicine, Department of Internal Medicine, Tachikawa Hospital, Tachikawa, Tokyo, Japan.
Hidefumi KohDivision of Pulmonary Medicine, Department of Internal Medicine, Tachikawa Hospital, Tachikawa, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We describe two patients who experienced serious multiple immune-related adverse events (irAEs), treatment interruption, and steroid administration. Despite these challenges, they achieved a remarkable antitumor effect beyond the expected. Various carcinomas demonstrated a possible correlation between the antitumor effect of immune checkpoint inhibitors and the intensity of irAEs, but few studies report on malignant pleural mesothelioma (MPM). Our two cases exhibited much stronger irAEs than usual. These two cases still demonstrated a complete response (CR) or near CR partial response, indicating a correlation between irAEs and the antitumor effect in MPM.

Indexed as

antitumor effectimmune-related adverse eventsipilimumabmalignant pleural mesotheliomanivolumab

Identifiers

PMID40225815
PMCPMC11991814

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.