ReviewRSC advances2025
Advancing protein biosensors: redefining detection through innovations in materials, mechanisms, and applications for precision medicine and global diagnostics.
Review in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Aptamer-based DNA nanoswitches for multiplexed protein detection.Chemical communications (Cambridge, England) · 2026Article
- Confined Catalysis of Enzymes: Enhancement Strategies, Materials, and Biosensor Applications.Journal of functional biomaterials · 2026Review
- Optical Biosensors-Principles of Operation and Applications.Micromachines · 2026Review
- Aptamer-based DNA nanoswitches for multiplexed protein detection.bioRxiv : the preprint server for biology · 2026Article
- A Sensitive Multichannel Fluorescent Polymer Sensor Array for the Detection of Protein Fluctuations in Serum.Sensors (Basel, Switzerland) · 2026Article
- Biomarker-Guided Drug Delivery Systems and Oral Bioavailability Enhancement.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Biodetection of Mycobacterium tuberculosis: nano-biosensors in detection; from principles to recent progresses.Journal of biological engineering · 2026Review
- DNA Nanostructure-Assembled Metallic Nanoparticles for Biosensing Applications.Molecules (Basel, Switzerland) · 2026Review
- Smart Biosensing Nanomaterials for Alzheimer's Disease: Advances in Design and Drug Delivery Strategies to Overcome the Blood-Brain Barrier.Biosensors · 2026Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protein biosensors are significant tools in modern diagnostics due to their exceptional sensitivity and specificity in detecting protein biomarkers critical for disease diagnosis, therapeutic monitoring, and biomedical research. Innovations in transduction methods, nanomaterials, and point-of-care system integration have spurred recent advancements in biosensor technology. This summary examines key developments in protein biosensors, focusing on their structure, applications, and future potential. Nanomaterial-enhanced electrochemical biosensors, such as graphene, polyaniline, and carbon nanotubes, offer improved signal transmission due to their large surface area and faster electron transfer rates. Label-free immunosensors activated with gold nanoparticles and MXene-based sensors capable of combined biomarker analysis for detecting ovarian cancer are notable examples. During the COVID-19 pandemic, colorimetric and fluorescence optical biosensors facilitated easier diagnostics. An example of this is the incorporation of SARS-CoV-2 detection technologies into mobile phones. Real-time, label-free tracking with molecular precision is now possible due to the development of new methods, such as CRISPR-based platforms and quartz crystal microbalance (QCM)-based biosensors. This advancement is crucial for effectively managing infectious diseases and cancer. Synthetic fluorescence biosensors increase diagnostics by improving the visualization of protein interactions and cellular communication. Despite these achievements, challenges related to scalability, sustainability, and regulatory compliance remain. Proposed solutions include sustainable biosensor manufacturing, artificial intelligence-enhanced analytics for efficacy evaluation, and multidisciplinary approaches to optimize interaction with decentralised diagnostic systems. This work demonstrates how protein biosensors can advance precision medicine and global health.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.