ArticleFrontiers in veterinary science2025
Immunogenicity and protective efficacy of seven candidate vaccines boosted with recombinant proteins, whole-cell bacterins of three serotypes of
Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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5 authors.
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Abstract
Introduction: Methods: Five hundred lung samples from calves and sheep with respiratory infection symptoms were analyzed. Three Results: S6 strains had the highest prevalence, with 43.07%. Interestingly, S6 strains expressed a prominent band at approximately 250 kDa, potentially causing haemorrhagic effects in mice. The S2 pellet performed best as an ELISA-coating antigen. The trivalent vaccine with Montanide™ ISA 206 VG provided the best protection in mice. Seropotency vaccine efficacy and challenge vaccine efficacy of trivalent vaccine were 95.8 and 100%, respectively. According to multinomial logistic regression analysis, the greatest odds ratio (0.97) was obtained from the trivalent vaccine. Conclusion: The haemorrhagic effects observed with S6 highlight the importance of including this serotype in future vaccines. The trivalent S6 vaccine with Montanide™ ISA 206 shows promise for improved protection against diverse
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