Evidence map›Paper›PMID 40225754›Full record

ArticleJournal of tissue engineering and regenerative medicine2024

Endothelial Cell-Derived Exosomes Inhibit Osteoblast Apoptosis and Steroid-Induced Necrosis of Femoral Head Progression by Activating the PI3K/Akt/Bcl-2 Pathway.

Jie Sun, Chen Yao, Wanxin Luo, Xingyu Ge, Wenjie Zheng, Chi Sun, Yafeng Zhang

Abstract read
In one paragraph

Article in Journal of tissue engineering and regenerative medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jie SunDepartment of Orthopaedics, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.ORCID https://orcid.org/0000-0002-8624-0245
Chen YaoDepartment of Orthopaedics, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.
Wanxin LuoDepartment of Orthopaedics, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.
Xingyu GeResearch Centre of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.
Wenjie ZhengResearch Centre of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.ORCID https://orcid.org/0000-0001-5987-5272
Chi SunDepartment of Geriatrics, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.ORCID https://orcid.org/0000-0003-4752-7603
Yafeng ZhangDepartment of Orthopaedics, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.ORCID https://orcid.org/0000-0002-6823-9961

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of the study was to investigate the therapeutic potential of exosomes secreted by endothelial cells (EC-exos) on steroid-induced osteonecrosis of femoral head (SNFH). First, we successfully obtained EC-exos through differential centrifugation. Then, the effects of EC-exos on mouse embryo osteoblast precursor (MC3T3-E1) cells under high concentration of dexamethasone (Dex) were analysed

Indexed as

ApoptosisEndothelial CellsExosomesFemur HeadFemur Head NecrosisOsteoblastsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktProto-Oncogene Proteins c-bcl-2Signal TransductionAnimalsCell LineCell MovementCell SurvivalDexamethasoneMaleDexamethasonePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktProto-Oncogene Proteins c-bcl-2

Identifiers

PMID40225754
PMCPMC11918886

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.