Evidence map›Paper›PMID 40225750›Full record

ArticleJournal of tissue engineering and regenerative medicine2024

Decellularisation and Characterisation of Porcine Pleura as Bioscaffolds in Tissue Engineering.

Thirapurasundari Vikranth, Tina Dale, Nicholas R Forsyth

Abstract read
In one paragraph

Article in Journal of tissue engineering and regenerative medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Thirapurasundari VikranthSchool of Pharmacy and Bioengineering Guy Hilton Research Centre Keele University, Keele, UK.ORCID https://orcid.org/0000-0002-6419-2676
Tina DaleSchool of Pharmacy and Bioengineering Guy Hilton Research Centre Keele University, Keele, UK.ORCID https://orcid.org/0000-0001-9461-8220
Nicholas R ForsythSchool of Pharmacy and Bioengineering Guy Hilton Research Centre Keele University, Keele, UK.ORCID https://orcid.org/0000-0001-5156-4824

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Persistent air leaks caused by thoracic surgery, physical trauma, or spontaneous pneumothoraces are a cause of patient morbidity with need for extended chest tube durations and surgical interventions. Current treatment measures involve mechanical closure of air leaks in the compromised pleura. Organ and membrane decellularisation offers a broad range of biomimetic scaffolds of allogeneic and xenogeneic origins, exhibiting innate tissue-specific characteristics. We explored a physicochemical method for decellularising porcine pleural membranes (PPM) as potential tissue-engineered surrogates for lung tissue repair. Decellularised PPM (dPPM) was characterised with histology, quantitative assays, mechanical testing, and sterility evaluation. Cytotoxicity and recellularisation assays assessed biocompatibility of decellularised PPM (dPPM). Haematoxylin and Eosin (H&E) staining showed an evident reduction in stained nuclei in the dPPM, confirmed with nuclear staining and analysis (

Indexed as

PleuraTissue EngineeringTissue ScaffoldsAnimalsExtracellular MatrixHumansSwine

Identifiers

PMID40225750
PMCPMC11918256

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.