Evidence map›Paper›PMID 40225583›Full record

ArticleTheranostics2025

Improved optogenetic modification of spiral ganglion neurons for future optical cochlear implants.

Anupriya Thirumalai, Jana Henseler, Marzieh Enayati, Kathrin Kusch, Roland Hessler, Tobias Moser, Antoine Tarquin Huet

Abstract read
In one paragraph

Article in Theranostics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anupriya ThirumalaiInstitute for Auditory Neuroscience, University Medical Center Göttingen, 37075 Göttingen, Germany.
Jana HenselerInstitute for Auditory Neuroscience, University Medical Center Göttingen, 37075 Göttingen, Germany.
Marzieh EnayatiInstitute for Auditory Neuroscience, University Medical Center Göttingen, 37075 Göttingen, Germany.
Kathrin KuschInstitute for Auditory Neuroscience, University Medical Center Göttingen, 37075 Göttingen, Germany.
Roland HesslerCluster of Excellence "Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells" (MBExC), University of Göttingen, Göttingen, Germany.
Tobias MoserInstitute for Auditory Neuroscience, University Medical Center Göttingen, 37075 Göttingen, Germany.
Antoine Tarquin HuetInstitute for Auditory Neuroscience, University Medical Center Göttingen, 37075 Göttingen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Optogenetic stimulation has become a promising approach for restoring lost body function. For example, partial restoration of vision has been achieved in a blind patient and preclinical proof-of-concept has been demonstrated for optogenetic hearing restoration. In preparation for clinical translation of hearing restoration, efficient and safe optogenetic modification of spiral ganglion neurons (SGNs) in the mature cochlea remained to be developed.

Indexed as

Cochlear ImplantsNeuronsOptogeneticsSpiral GanglionAnimalsChannelrhodopsinsCochleaDependovirusGenetic VectorsGerbillinaeHumansChannelrhodopsinscochlear optogenetic stimulationmicrocatheter-based administrationoptical cochlear implantsspiral ganglion neurons.viral vector delivery

Identifiers

PMID40225583
PMCPMC11984395

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.