Evidence map›Paper›PMID 40225571›Full record

ReviewTheranostics2025

Leveraging adenosine triphosphate for cancer theranostics.

Yuhan Li, Xinyu Zhang, Jianhua Wang, Kexin Wang, Boya Li, Xianghe Qiao, Wei He, Jinghua Cai, Danfeng Liu, Lei-Lei Yang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Theranostics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuhan LiDepartment of Stomatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Xinyu ZhangDepartment of Stomatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Jianhua WangDepartment of Stomatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Kexin WangDepartment of Stomatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Boya LiDepartment of Stomatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Xianghe QiaoDepartment of Stomatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Wei HeDepartment of Stomatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Jinghua CaiDepartment of Stomatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Danfeng LiuDepartment of Stomatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Lei-Lei YangDepartment of Stomatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Manipulation of the biochemical composition of the tumor microenvironment (TME) is a thriving research area in cancer treatment. Adenosine triphosphate (ATP), a key biochemical component, serves as an energy source for cancer cell proliferation. Notably, ATP can also act as a potent signal transducer to prime anti-tumor immune responses. There is increasing attention given to both the tumor-promoting and tumor-inhibiting roles of ATP in the context of possible new treatments for cancer. ATP levels in the TME are known to be significantly greater than in non-tumor tissues. This disparity presents an opportunity to exploit the ATP response for the delivery of anti-tumor drugs and tumor diagnosis. In this article, we provide a comprehensive overview of the existing strategies and mechanisms for ATP-based therapy and cancer diagnosis. We also discuss the current challenges in the field and propose potential areas for future research, to provide researchers with insights to further investigate the potential of ATP in cancer theranostics.

Indexed as

Adenosine TriphosphateNeoplasmsTheranostic NanomedicineAnimalsAntineoplastic AgentsHumansPrecision MedicineTumor MicroenvironmentAdenosine TriphosphateAntineoplastic AgentsAdenosine triphosphateATP-based therapyATP responseCancer theranosticsTumor microenvironment

Identifiers

PMID40225571
PMCPMC11984400

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.