Evidence map›Paper›PMID 40225545›Full record

ArticleCureus2025

Dabigatran Combined With Benztropine Ameliorates Cobalt Chloride-Induced Parkinsonism in Rats, Restores Protease-Activated Receptor 1 (PAR1), and Mitigates Oxidative Stress.

Sherine Abdelmissih, Laila Ahmed Rashed, Mohamed Sharif Ismail Negm, Walaa Mohamed Sayed, Hesham M Mahmoud, Soha Elmorsy

Abstract read
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In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sherine AbdelmissihDepartment of Medical Pharmacology, Faculty of Medicine Kasr Al-Ainy, Cairo University, Cairo, EGY.
Laila Ahmed RashedDepartment of Medical Biochemistry and Molecular Biology, Faculty of Medicine Kasr Al-Ainy, Cairo University, Cairo, EGY.
Mohamed Sharif Ismail NegmDepartment of Pathology, Faculty of Medicine Kasr Al-Ainy, Cairo University, Cairo, EGY.
Walaa Mohamed SayedDepartment of Anatomy and Embryology, Faculty of Medicine Kasr Al-Ainy, Cairo University, Cairo, EGY.
Hesham M MahmoudDepartment of Medical Pharmacology, Faculty of Medicine Kasr Al-Ainy, Cairo University, Cairo, EGY.
Soha ElmorsyDepartment of Medical Pharmacology, Faculty of Medicine Kasr Al-Ainy, Cairo University, Cairo, EGY.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe presumed implication of thromboembolic and oxidative stress pathways in parkinsonism guided the current research toward the exploration of the anticoagulant dabigatran etexilate (DE) as a thrombin inhibitor in the cobalt chloride (CoCl

methodsOral CoCl

resultsBM+DE restored the number of rears to the control level, compared to being reduced in the CIP model. BM+DE restored the first, second, third, and average displacement distances to the control level, compared to being reduced in the CIP model. BM+DE was superior to either BM or DE in restoring the time to finish eating pasta and the number of adjustments of forepaws while eating to control levels after being affected in the CIP model. BM+DE restored DA to the control level and was superior to DE in restoring D

conclusionBM+DE offers a therapeutic potential for parkinsonism triggered by chronic exposure to CoCl

Indexed as

adenosinebenztropinecobalt chloridedabigatrandopamineendothelin 1glutathionemalondialdehydeparkinsonismprotease-activated receptor 1

Identifiers

PMID40225545
PMCPMC11991752

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.