ReviewCureus2025
Beyond Routine Monitoring: A Comprehensive Review of Direct Oral Anticoagulants and the Role of Coagulation Profiles in Their Management.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Direct oral anticoagulants (DOACs) have revolutionized anticoagulation therapy, providing effective and safe management of thrombosis and related conditions. As their use continues to grow, accurately monitoring their effects is essential to achieve optimal patient outcomes. Traditional coagulation tests, such as prothrombin time (PT) and activated partial thromboplastin time, have long been used to evaluate clotting function and bleeding risk in patients on anticoagulants. However, these standard tests often fall short with DOACs due to complex interactions between the drugs and the assays. While PT offers some insight into coagulation, its reliability for drugs like apixaban, one of the most commonly prescribed DOACs, remains debated. This limitation underscores the need for alternative monitoring strategies, such as the modified diluted PT, which shows promise in providing more accurate assessments of DOAC levels. This review discusses the pharmacokinetics of DOACs, their impact on standard coagulation tests, and various factors - such as liver disease and drug interactions - that complicate these assessments. Additionally, it highlights the importance of incorporating specific assays, including anti-factor Xa activity and dilute thrombin time, for precise anticoagulation management. By synthesizing current evidence, this review aims to identify improved methods for monitoring DOAC therapy, guide clinicians in optimizing anticoagulation treatment, and ultimately enhance patient outcomes.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.