Evidence map›Paper›PMID 40225498›Full record

ArticleCureus2025

Development of Multiple Subcutaneous Lipomas After Six Months of Hormone Replacement Therapy: A Case Report.

Kazuyoshi Iijima, Yoshihito Mima

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Kazuyoshi IijimaDepartment of Dermatology, Teikyo University Mizonokuchi Hospital, Kawasaki, JPN.
Yoshihito MimaDepartment of Dermatology, Tokyo Metropolitan Police Hospital, Tokyo, JPN.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lipomas are common benign soft tissue tumors composed of mature adipocytes, typically presenting as slow-growing, painless subcutaneous nodules. While the underlying etiology remains unclear, various factors have been proposed as potential contributors. In some individuals, multiple subcutaneous lipomas can develop, and their occurrence has been considered in relation to systemic conditions or familial predisposition. Hormone replacement therapy (HRT), commonly used for menopausal symptom management, influences lipid metabolism and angiogenesis through hormonal signaling pathways; however, its potential role in lipoma formation remains uncertain. Herein, we present a case of a 57-year-old woman who developed multiple subcutaneous lipomas on the thighs and buttocks after initiating HRT. This case highlights a possible association between hormonal changes and lipoma formation, emphasizing the importance of further research into the mechanisms underlying adipose tissue growth.

Indexed as

estrogenhormone replacement therapylipomatosismultiple lipomasvegf

Identifiers

PMID40225498
PMCPMC11993897

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.