ArticleCureus2025
Comparison of Intraoperative Blood Loss in Monopolar Transurethral Resection of the Prostate With and Without Two Weeks of Preoperative Dutasteride.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionMonopolar transurethral resection of the prostate (TURP) is a common surgical procedure for benign prostatic hyperplasia, often associated with significant intraoperative blood loss. Dutasteride, a 5-alpha reductase inhibitor, has been recommended to reduce perioperative bleeding by decreasing vascularity within the prostate.
objectiveThe purpose of this study was to investigate the impact of pre-operative administration of dutasteride for a duration of two weeks on the reduction of intra-operative blood loss in patients undergoing monopolar TURP.
methodThis prospective, two-armed, quasi-experimental study enrolled 132 patients based on the specified inclusion criteria. Patients who fulfilled the criteria for monopolar TURP were administered 0.5mg dutasteride for two weeks prior to their TURP procedure. Afterward, these patients were admitted to the hospital ward and underwent the necessary preparations for the surgery. During the surgical procedure, the intra-operative irrigation fluid was quantified and collected and the hemoglobin (Hb) was tested. The amount of blood loss was then determined using an appropriate equation. The assessment of blood loss was conducted using several indicators, including the analysis of irrigation fluid, the measurement of Hb levels in the irrigation fluid, the preoperative Hb levels, and the weight of the resected tissue.
resultA significant decline in blood loss was observed in the interventional group in comparison to the control group. The average blood loss observed in Group A was 296ml, whereas in Group B it was 370ml. Furthermore, the blood loss per gram was found to be 11.7ml/g in Group A and 14.7ml/g in Group B. The mean operative time for Group A was recorded as 42 minutes, while Group B had a mean operative time of 49 minutes.
conclusionThe study's findings indicate a significant superiority of administering dutasteride before surgery for a duration of two weeks. A substantial reduction in both intraoperative blood loss and blood loss per gram is seen in patients who underwent monopolar TURP with dutasteride.
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