ArticleCureus2025
Acetazolamide-Induced Liver Injury: A Case Report and Literature Review.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acetazolamide is a carbonic anhydrase inhibitor, which has been very rarely associated with drug-induced liver injury (DILI). This report presents a case of an elderly male who developed severe but asymptomatic DILI associated with acetazolamide use. Severity was established based on markedly elevated serum transaminases. Subsequent rechallenge of acetazolamide at a higher dose resulted in increased severity of the elevations, further suggesting a causative effect. Liver function tests ultimately improved after acetazolamide discontinuation. This case underscores the need for early recognition and timely discontinuation of acetazolamide to prevent worsening liver injury and optimize clinical outcomes. Only two prior documented cases of acetazolamide-induced DILI are found in the medical literature. A detailed review and comparison of those prior cases have been undertaken in the discussion of this case presentation.
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Registered trials
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