Evidence map›Paper›PMID 40225433›Full record

ReviewCureus2025

Unmasking Subclinical Atherosclerosis: The Impact of Carotid Ultrasound on the Evaluation of Patients With Rheumatoid Arthritis.

Ramiro A Moreno, Cesar Ayala Ugarte, Emmanuel Amaro Hernández, Eric Sánchez Olivan, Daniel I Leal Villanueva, Fabiola Flores Serrano, Diana Laura Rojas de León, Azul F Zaragoza Pérez, Angie Pamela Reyes Loaiza, Fernanda J Velázquez Domínguez and 4 more

Abstract readReview
In one paragraph

Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ramiro A MorenoCardiology, Autonomous University of Nuevo León, Monterrey, MEX.
Cesar Ayala UgarteCardiology, Autonomous University of Guadalajara, Guadalajara, MEX.
Emmanuel Amaro HernándezGeneral Medicine, Monterrey Institute of Technology and Higher Education, Monterrey, MEX.
Eric Sánchez OlivanCardiology, National Autonomous University of Mexico, Mexico, MEX.
Daniel I Leal VillanuevaGeneral Medicine, Michoacan University of Saint Nicholas of Hidalgo, Morelia, MEX.
Fabiola Flores SerranoGeneral Medicine, Autonomous University of Guadalajara, Guadalajara, MEX.
Diana Laura Rojas de LeónGeneral Medicine, Monterrey Institute of Technology and Higher Education, Mexico, MEX.
Azul F Zaragoza PérezGeneral Medicine, Siglo XXI University Campus, Apodaca, MEX.
Angie Pamela Reyes LoaizaGeneral Medicine, Technical University of Machala, Machala, ECU.
Fernanda J Velázquez DomínguezGeneral Medicine, Autonomous University of the State of Morelos, Cuernavaca, MEX.
Cesar E Ibarra HernándezGeneral Medicine, University of Guadalajara, Guadalajara, MEX.
María de la Luz Flores ReséndizGeneral Medicine, University of the Valley of Mexico, Saltillo, MEX.
Jaqueline L CastilloGeneral Medicine, Autonomous University of Guadalajara, Guadalajara, MEX.
Jose R Flores ValdésGeneral Practice, Oncology Consultants, Houston, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rheumatoid arthritis (RA) is the most prevalent autoimmune disease, characterized by chronic joint inflammation and systemic symptoms, particularly affecting cardiovascular health through atherosclerosis development. This study investigates the role of carotid ultrasound in detecting atherosclerosis in RA patients by measuring carotid intima-media thickness (CIMT). We conducted a comprehensive review of studies published from 2017 to 2024, sourced from PubMed, focusing specifically on CIMT measurements in RA patients. Our analysis included eight studies involving a total of 1,242 participants. The results demonstrate that increased CIMT measurements in RA patients are associated with a higher risk of subclinical atherosclerosis. Notably, most studies (N = 7) reported statistically significant increases in CIMT, while only one study found no significant difference. These findings suggest that CIMT is a valuable tool for assessing cardiovascular risk in RA patients, advocating for the more frequent use of carotid ultrasound as a noninvasive clinical assessment method for this population. However, further multicentric randomized controlled trials and enhanced training for healthcare providers are necessary to ensure accurate CIMT measurements in routine practice.

Indexed as

arterial stiffnessatherosclerosiscardiovascular riskcarotid ultrasoundendothelial dysfunctioninflammationintima-media thicknessrheumatoid arthritissubclinical atherosclerosisultrasonography

Identifiers

PMID40225433
PMCPMC11993276

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.