Evidence map›Paper›PMID 40225396›Full record

ArticleKidney international reports2025

Similar Efficacy in Belatacept-Converted Kidney Transplant Recipients With Steroid-Avoiding Regimen.

Nathalie Chavarot, Lara Cabezas, Hannah Kaminski, Helene Lazareth, Mélanie Try, Juliette Leon, Anne Scemla, Thomas Jouve, Eric Thervet, Dany Anglicheau and 3 more

Abstract read
In one paragraph

Article in Kidney international reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Belatacept in Kidney Transplantation: Reflecting on the Past, Shaping the Future.Transplant international : official journal of the European Society for Organ Transplantation · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Nathalie ChavarotNephrology and Kidney Transplantation Department, Necker Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
Lara CabezasNephrology, Hemodialysis, Apheresis and Kidney Transplantation Department, Grenoble University Hospital, Grenoble, France.
Hannah KaminskiDepartment of Nephrology, Transplantation, Dialysis and Apheresis, Bordeaux University Hospital, Bordeaux, France.
Helene LazarethNephrology Department, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France.
Mélanie TryNephrology and Kidney Transplantation Department, Necker Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
Juliette LeonNephrology and Kidney Transplantation Department, Necker Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
Anne ScemlaNephrology and Kidney Transplantation Department, Necker Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
Thomas JouveNephrology, Hemodialysis, Apheresis and Kidney Transplantation Department, Grenoble University Hospital, Grenoble, France.
Eric ThervetNephrology Department, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France.
Dany AnglicheauNephrology and Kidney Transplantation Department, Necker Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
Lionel CouziDepartment of Nephrology, Transplantation, Dialysis and Apheresis, Bordeaux University Hospital, Bordeaux, France.
Rebecca Sberro-SoussanNephrology and Kidney Transplantation Department, Necker Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
Johan NobleNephrology, Hemodialysis, Apheresis and Kidney Transplantation Department, Grenoble University Hospital, Grenoble, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Belatacept offers a valuable alternative to calcineurin inhibitors (CNIs) for reducing toxicity in kidney transplant recipients (KTRs). No study has evaluated the efficacy and safety of late-conversion belatacept with steroid avoidance in KTRs. Methods: This retrospective multicentric study evaluated the efficacy and safety of a belatacept-based steroid-avoiding therapy, in comparison with concomitant steroid use. The study included KTRs from 4-French transplant centers who were converted to belatacept at least 6 months posttransplantation. Results: Overall, 512 KTRs were converted to belatacept in a median time of 38 (15.7-83.2) months after kidney transplantation (KT), including 199 patients without steroids after conversion (BelaS-). Median follow-up time was 78.9 (50.3-129.4) months. Compared with the 313 KTRs who had concomitant steroid use (BelaS+), BelaS- patients had a similar acute rejection (AR) rate (19 [6.1%] and 12 [6.0%] patients, Conclusion: Avoiding steroids in KTRs who are late-converted to belatacept is associated with a similar efficacy along with lower mortality and reduced incidence of severe infections in selected low-sensitized patients.

Indexed as

acute rejectionbelataceptkidney transplant recipientssteroid avoiding

Identifiers

PMID40225396
PMCPMC11993219

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.