Evidence map›Paper›PMID 40225352›Full record

ArticleTheScientificWorldJournal2025

Bioactivity, Efficacy, and Safety of a Wound Healing Ointment With Medicinal Plant Bioactives: In Vitro and In Vivo Preclinical Evaluations.

Juliana Ferreira Floriano, Daniel Rodrigues, Rie Ohara, Nara Lígia Martins Almeida, Vanessa Soares Lara, Patricia Sartorelli, Carlos Frederico de Oliveira Graeff, Simone Dos Santos Grecco, Alejandra Hortencia Miranda González, Paulo Henrique Perlatti D'Alpino

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in TheScientificWorldJournal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Juliana Ferreira FlorianoImperial College London, National Heart and Lung Institute, London, UK.ORCID https://orcid.org/0000-0002-7423-7591
Daniel RodriguesBiotechnology and Innovation in Health Program, Universidade Anhanguera de São Paulo (UNIAN), São Paulo, Brazil.ORCID https://orcid.org/0000-0001-6634-0073
Rie OharaUndergraduate Program, Medical School, Universidade Nove de Julho, Bauru, São Paulo, Brazil.ORCID https://orcid.org/0000-0003-4430-0016
Nara Lígia Martins AlmeidaDepartment of Surgery, Stomatology, Pathology and Radiology, Bauru School of Dentistry, University of São Paulo (USP), Bauru, São Paulo, Brazil.ORCID https://orcid.org/0000-0001-7039-1551
Vanessa Soares LaraDepartment of Surgery, Stomatology, Pathology and Radiology, Bauru School of Dentistry, University of São Paulo (USP), Bauru, São Paulo, Brazil.ORCID https://orcid.org/0000-0003-1986-0003
Patricia SartorelliDepartment of Chemistry, Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo, Diadema, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-1624-8145
Carlos Frederico de Oliveira GraeffDepartment of Physics, School of Sciences, POSMAT-Post-Graduate Program in Materials Science and Technology, São Paulo State University (UNESP), Bauru, São Paulo, Brazil.ORCID https://orcid.org/0000-0003-0162-8273
Simone Dos Santos GreccoDepartment of Chemistry, Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo, Diadema, São Paulo, Brazil.ORCID https://orcid.org/0000-0003-0716-0368
Alejandra Hortencia Miranda GonzálezDepartment of Research and Development (R&D) and Innovation Center, Triplet Biotechnology Solutions, Inc., Bauru, São Paulo, Brazil.ORCID https://orcid.org/0000-0003-2982-8736
Paulo Henrique Perlatti D'AlpinoUndergraduate Program, Medical School, Universidade Nove de Julho, Bauru, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-1829-409X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic wounds have a significant impact on patients' quality of life, necessitating the management of pain, infection, bleeding, and emotional challenges. Debridement, which involves the removal of nonviable tissue, is crucial for promoting wound healing. In addition to surgical methods, cost-effective alternatives such as local solutions and ointments with biological properties have been explored. The use of natural compounds with anti-inflammatory, antibacterial, and collagen-synthesizing abilities holds promise for wound healing. This in vitro and in vivo preclinical study aimed to assess the safety and effectiveness of a wound healing ointment containing bioactive ingredients derived from medicinal plants (extracts, essential oils, and vegetable oils). The chemical composition of the ointment was characterized using Fourier transform infrared (FTIR) spectroscopy to gain insights into its synergistic action. Preclinical tests were conducted following standardized protocols. FTIR analysis revealed similarities between the product's spectrum and that of bioactive compounds. The in vitro tests demonstrated that all formulations of the ointment induced no cell death, DNA damage, or acute toxicity in cell cultures (

Indexed as

Plant ExtractsPlants, MedicinalWound HealingAnimalsHumansMaleMiceOils, VolatileOintmentsRatsSpectroscopy, Fourier Transform InfraredOils, VolatileOintmentsPlant Extractsbiocompatibilitychronic woundsnatural compoundspreclinical testswound care

Identifiers

PMID40225352
PMCPMC11986185

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.