ArticleFrontiers in nutrition2025
Serum manganese and its association with non-alcoholic fatty liver disease: findings from NHANES.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Serum Levels of Trace Elements and Minerals in Non-alcoholic Fatty Liver Disease Patients with and without Type 2 Diabetes are Associated with Metabolic Risk Markers.Biological trace element research · 2026Article
- Article
- Gut to brain: essential micronutrient and trace element manganese transport, function and toxicity.Frontiers in physiology · 2025Review
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Authors and funding
3 authors.
Funding
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Abstract
Objective: This study examines the link between serum manganese (Mn) levels and non-alcoholic fatty liver disease (NAFLD), with a focus on gender differences. Methods: Utilizing data from the NHANES 2017-2018, we included participants aged 18 and older, excluding those without ultrasonic liver assessment, serum Mn data, or with hepatitis or significant alcohol use. The final analysis comprised 4,294 individuals, with 2,708 in the NAFLD group and 1,586 in the non-NAFLD group. Serum Mn was quantified via inductively coupled plasma mass spectrometry. We compared demographic and health-related variables between groups using appropriate statistical tests and categorized participants into quartiles based on Mn levels. Multivariate logistic regression and spline regression analyses were conducted to evaluate the association between serum Mn and NAFLD risk by gender. Results: Serum Mn was significantly elevated in the NAFLD group compared to non-NAFLD individuals (9.06 vs. 9.33 μg/L, Z = 2.815, Conclusion: Higher serum Mn levels are significantly associated with increased NAFLD risk in both genders, highlighting the need for gender-specific considerations in future studies and clinical practices.
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