ArticleAlzheimer's & dementia (New York, N. Y.)
Physical activity complexity, cognition, and risk of cognitive impairment and dementia in the Baltimore Longitudinal Study of Aging.
Article in Alzheimer's & dementia (New York, N. Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Ecological momentary pain and physical activity volume and patterns in older adults with chronic multisite pain.BMC geriatrics · 2026Observational
- Personal Time, Parental Fairness, School Adjustment and Physical Activity Levels as Indicators of Executive Functions in Children and Adolescents.Behavioral sciences (Basel, Switzerland) · 2026Article
- Towards an AI biomedical scientist: Accelerating discoveries in neurodegenerative disease.The journal of prevention of Alzheimer's disease · 2025Article
- Physical activity complexity, cognition, and risk of cognitive impairment and dementia in the Baltimore Longitudinal Study of Aging.Alzheimer's & dementia (New York, N. Y.)Article
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Authors and funding
12 authors.
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Abstract
introductionStudies on physical activity (PA) and dementia mainly focus on activity quantity or intensity. Yet PA requires neuro-coordination of movement, and it is unclear whether complexity of daily activity varies by cognitive status. Thus, we examined the association between PA complexity, using multiscale entropy, and cognitive function, mild cognitive impairment (MCI), and dementia in older adults in the Baltimore Longitudinal Study of Aging (BLSA).
methodsA total of 637 older adults (age 73.9 ± 11.3 years) in the BLSA completed a 7-day wrist-worn accelerometer assessment and neuropsychological tests from 2015 to 2020. Using logistic regression and structural equation modeling, we examined cross-sectional associations of PA complexity with MCI/dementia and cognition. Cross-lagged panel models (CLPMs) were used to assess bidirectional associations at baseline and 2-year follow-up. Multivariable models were adjusted for age, sex, race, education years, body mass index, and comorbidities.
resultsParticipants in the lowest tertile of PA complexity had over double the odds of MCI/dementia (odds ratio = 2.63, 95% confidence interval [CI]: 1.02 to 6.79, DISCUSSION: Lower complexity of accelerometry-detected movement is associated with poorer cognition and higher risk of MCI/dementia. Future studies should explore whether low PA complexity is an early indicator of dementia. Highlights: Prior studies mainly focused on quantity or intensity of physical activity.Poorer cognitive function was associated with lower complexity of daily activity.Lower complexity of physical activity may be an early indicator of dementia.
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