ArticleRheumatology advances in practice2025
Osteoarthritis after major combat trauma: the Armed Services Trauma Rehabilitation Outcome Study.
Article in Rheumatology advances in practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Understanding long-term physical and psychosocial outcomes from conflict to rehabilitation through the ADVANCE cohort.Communications medicine · 2026Review
- Influence of major trauma and lower limb loss on radiographic progression and incidence of knee osteoarthritis and pain: a comparative and predictive analysis from the ADVANCE study.Arthritis research & therapy · 2026Article
- Prevalence, incidence, and progression of hip osteoarthritis in a young military population: The ADVANCE cohort study.Osteoarthritis and cartilage open · 2025Article
- Insights into knee post-traumatic osteoarthritis pathophysiology from the relationship of serum biomarkers to radiographic features in the ADVANCE cohort.Arthritis research & therapy · 2025Article
- Evaluating the physical and psychosocial impact of serious physical combat injuries in UK armed forces personnel-the ADVANCE cohort study.European journal of epidemiology · 2025Article
- The Relationship between Military Combat and Cardiovascular Risk: A Systematic Review and Meta-Analysis.International journal of vascular medicine · 2019Review
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Authors and funding
12 authors.
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Abstract
Objective: To investigate the differences in clinical and radiographic knee OA markers between injured and uninjured UK service personnel. Methods: This study was a cross-sectional analysis, 8 years post-injury, of a prospective cohort study. The Knee Injury and Osteoarthritis Outcome Scores (KOOS), radiographic Kellgren and Lawrence (KL) scores and Osteoarthritis Research Society International scores (joint space narrowing, sclerosis, osteophytes) were obtained from 565 uninjured and 579 matched (on sex, age, rank, regiment and role on deployment) major combat injured participants from the Armed Services Trauma Rehabilitation Outcome study; 35 had a knee injury and 142 had an amputation without knee injury. Kruskal-Wallis tests were used to compare between groups for KOOS and radiographic measures. A multiple logistic regression was performed on the effects of injury on radiographic features. Results: The mean age at injury was 25.7 years (s.d. 5.2). Injured participants demonstrated worse KOOS values for pain {median 89 [interquartile range (IQR) 72-100] Conclusion: Major combat trauma (in addition to knee injury or amputation) has a substantial effect on the development of KOA.
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