Evidence map›Paper›PMID 40225223›Full record

ArticleInternational journal of nanomedicine2025

Green Synthesis of Zinc Oxide Nanoparticles as a Promising Nanomedicine Approach for Anticancer, Antibacterial, and Anti-Inflammatory Therapies.

Nahed Ahmed Hussien, Maha Abd El Fattah Khalil, Michael Schagerl, Sameh Samir Ali

Abstract read
In one paragraph

Article in International journal of nanomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Green synthesis of zinc oxide nanoparticles usingParasite epidemiology and control · 2026
    Article
  9. Review
  10. Review
  11. Review
  12. Phyto-Mediated Zinc Oxide Nanoparticles fromLife (Basel, Switzerland) · 2025
    Article
  13. Article
  14. Biogenic Metal Transformations fromInternational journal of nanomedicine · 2025
    Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nahed Ahmed HussienDepartment of Biology, College of Science, Taif University, Taif, 21944, Saudi Arabia.ORCID 0000-0001-7019-9682
Maha Abd El Fattah KhalilDepartment of Biology, College of Science, Taif University, Taif, 21944, Saudi Arabia.ORCID 0000-0003-0470-1675
Michael SchagerlDepartment of Functional and Evolutionary Ecology, University of Vienna, Vienna, A-1030, Austria.ORCID 0000-0002-8277-7205
Sameh Samir AliBotany Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt.ORCID 0000-0002-7033-8387

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aim: The rapid advancement of nanotechnology has opened new avenues for biomedical applications, particularly in antimicrobial, anti-inflammatory, and anticancer therapies. Green synthesis of zinc oxide nanoparticles (ZnO-NPs) using plant extracts offers an eco-friendly and biocompatible alternative to traditional chemical methods. This study explores the synthesis of ZnO-NPs using Methods: Clove bud extract-zinc oxide nanoparticles (CBE-ZnO-NPs) were synthesized and characterized using scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), Fourier-transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), and Brunauer-Emmett-Teller (BET) analyses to confirm their size, morphology, elemental composition, and surface properties. The anticancer efficacy was tested against tongue carcinoma (HNO-97) cells using the sulforhodamine B (SRB) assay. Antibacterial activity was assessed against Results: The SEM analysis confirmed a non-uniform shape of ZnO-NPs, while FTIR revealed functional groups responsible for stabilization and bioactivity. DLS measurements indicated an average particle size of 249.8 nm with a zeta potential of -3.38 mV, ensuring moderate colloidal stability. BET analysis demonstrated a high porosity (30.039 m²/g) and a mean particle size of 19.52 nm. CBE-ZnO-NPs exhibited moderate anticancer activity against tongue carcinoma cells (IC Conclusion: This study highlights the potential of CBE-ZnO-NPs as a promising multi-functional nanomaterial with potent antibacterial, anticancer, and anti-inflammatory properties. The findings pave the way for further exploration of ZnO-based nanotherapeutics in biomedical applications, particularly in cancer therapy, infection control, and inflammatory disorders.

Indexed as

Anti-Bacterial AgentsAnti-Inflammatory AgentsAntineoplastic AgentsMetal NanoparticlesNanoparticlesZinc OxideAnimalsCell Line, TumorGreen Chemistry TechnologyHumansMiceMicrobial Sensitivity TestsNanomedicineParticle SizePlant ExtractsRAW 264.7 CellsAnti-Bacterial AgentsAnti-Inflammatory AgentsAntineoplastic AgentsPlant ExtractsZinc Oxidebiomedical applicationsgreen synthesisnanotechnologySyzygium aromaticumzinc oxide nanoparticles

Identifiers

PMID40225223
PMCPMC11992474

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.