Evidence map›Paper›PMID 40225218›Full record

ReviewInternational journal of nanomedicine2025

Recent Research Advances in Multi-Functional Diallyl Trisulfide (DATS): A Comprehensive Review of Characteristics, Metabolism, Pharmacodynamics, Applications, and Drug Delivery Systems.

Maoru Wang, Jiangping Yu, Hui Xu, Kexin Xu, Muhammad Sohail, Jisheng Wang, Hong Ning, Jianqiao Zhang, Bin Yu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of nanomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Maoru Wang *Drug Dispensing Department, The Third Hospital of Mianyang, Sichuan Mental Health Center, Mianyang, Sichuan, People's Republic of China.
Jiangping Yu *NHC Key Laboratory of Nuclear Technology Medical Transformation (MIANYANG CENTRAL HOSPITAL), Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, Sichuan, People's Republic of China.
Hui XuSchool of Pharmacy, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Key Laboratory of Molecular Pharmacology and Drug Evaluation, Yantai University, Yantai, Shandong, People's Republic of China.ORCID 0000-0002-0136-4784
Kexin XuSchool of Pharmacy, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Key Laboratory of Molecular Pharmacology and Drug Evaluation, Yantai University, Yantai, Shandong, People's Republic of China.
Muhammad SohailKey Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, Zhejiang Engineering Research Center of Interventional Medicine Engineering and Biotechnology, Key Laboratory of Precision Medicine of Lishui City, Lishui Hospital of Zhejiang University, Lishui, Zhejiang, People's Republic of China.
Jisheng WangDrug Dispensing Department, The Third Hospital of Mianyang, Sichuan Mental Health Center, Mianyang, Sichuan, People's Republic of China.
Hong NingNHC Key Laboratory of Nuclear Technology Medical Transformation (MIANYANG CENTRAL HOSPITAL), Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, Sichuan, People's Republic of China.
Jianqiao ZhangClinical Trials Research Center, Department of Pharmacy, Binzhou Medical University Affiliated Zibo Central Hospital, Zibo, Shandong, People's Republic of China.ORCID 0000-0002-4941-7013
Bin YuNHC Key Laboratory of Nuclear Technology Medical Transformation (MIANYANG CENTRAL HOSPITAL), Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, Sichuan, People's Republic of China.ORCID 0000-0002-0397-6610

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diallyl trisulfide (DATS) is an organic sulfur compound derived from garlic (Allium sativum L). DATS is characterized by its oily and volatile nature, exhibiting insolubility in water and ethanol, while being miscible with ether. This property enhances its extraction process and expands its applicability across various fields. Recent studies have elucidated the diverse effects of DATS, demonstrating significant progress in healthcare, the food industry, and nanoformulation research. Research on DATS is currently limited, hindering a comprehensive understanding and appreciation of its possibilities for future development. This review offers an in-depth examination of the characteristics of DATS, highlighting the significant advancements and benefits achieved in the fields of drug metabolism, pharmacological effects, clinical trials, food chemistry applications, and nanoformulation research over the past two decades. In addition, this review examines the future prospects of DATS, emphasizing its current development status and challenges, while serving as a crucial reference for advancing research, application, and innovation in the field.

Indexed as

Allyl CompoundsDrug Delivery SystemsSulfidesAnimalsGarlicHumansAllyl Compoundsdiallyl trisulfideSulfidesclinical treatmentDATSdiallyl trisulfidedrug delivery systemsfood applicationsmetabolismpharmacological effects

Identifiers

PMID40225218
PMCPMC11994080

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.