Evidence map›Paper›PMID 40225166›Full record

ArticleHuman mutation2023

Disruption of Intracellular Calcium Homeostasis Leads to ERLIN2-Linked Hereditary Spastic Paraplegia in Patient-Derived Stem Cell Models.

Xintong Zhu, Xiaoyin Tan, Junwen Wang, Limeng Dai, Jia Li, Xingying Guan, Ziyi Wang, Mao Zhang, Jun Hu, Yun Bai and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human mutation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xintong Zhu *Department of Medical Genetics, College of Basic Medical Sciences, Army Medical University, Chongqing 400038, China.
Xiaoyin Tan *Department of Medical Genetics, College of Basic Medical Sciences, Army Medical University, Chongqing 400038, China.
Junwen WangDepartment of Medical Genetics, College of Basic Medical Sciences, Army Medical University, Chongqing 400038, China.
Limeng DaiDepartment of Medical Genetics, College of Basic Medical Sciences, Army Medical University, Chongqing 400038, China.
Jia LiDepartment of Medical Genetics, College of Basic Medical Sciences, Army Medical University, Chongqing 400038, China.
Xingying GuanDepartment of Medical Genetics, College of Basic Medical Sciences, Army Medical University, Chongqing 400038, China.
Ziyi WangDepartment of Medical Genetics, College of Basic Medical Sciences, Army Medical University, Chongqing 400038, China.
Mao ZhangDepartment of Medical Genetics, College of Basic Medical Sciences, Army Medical University, Chongqing 400038, China.
Jun HuDepartment of Neurology, Southwest Hospital, Army Medical University, Chongqing 400038, China.
Yun BaiDepartment of Medical Genetics, College of Basic Medical Sciences, Army Medical University, Chongqing 400038, China.ORCID 0000-0002-6681-3122
Hong GuoDepartment of Medical Genetics, College of Basic Medical Sciences, Army Medical University, Chongqing 400038, China.ORCID 0000-0002-3244-1340

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hereditary spastic paraplegia (HSP) is a category of neurodegenerative illnesses with significant clinical and genetic heterogeneity. Homozygous truncated variants of the

Indexed as

CalciumHomeostasisInduced Pluripotent Stem CellsMembrane ProteinsSpastic Paraplegia, HereditaryApoptosisEndoplasmic Reticulum StressFemaleHeterozygoteHumansInositol 1,4,5-Trisphosphate ReceptorsMaleMutation, MissensePedigreeUbiquitin-Protein LigasesCalciumERLIN2 protein, humanInositol 1,4,5-Trisphosphate ReceptorsMembrane ProteinsUbiquitin-Protein Ligases

Identifiers

PMID40225166
PMCPMC11919107

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.