Evidence map›Paper›PMID 40225069›Full record

ArticleTranslational pediatrics2025

The hidden ophthalmic dangers of steroids in COVID-19 treatment: a case report.

Zhehuan Zhang, Tianchen Wu, Wenwen Xu, Di Hu, Chenhao Yang

Abstract readCase Reports
In one paragraph

Article in Translational pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhehuan ZhangDepartment of Ophthalmology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.ORCID https://orcid.org/0000-0003-1196-270X
Tianchen WuDepartment of Ophthalmology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Wenwen XuDepartment of Ophthalmology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Di HuDepartment of Ophthalmology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Chenhao YangDepartment of Ophthalmology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.ORCID https://orcid.org/0000-0003-3818-037X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Coronavirus disease 2019 (COVID-19) has been coexisted with us, and corticosteroids are now recommended for patients with severe COVID-19 respiratory failure. Steroid treatments may increase intraocular pressure (IOP) and steroid-induced glaucoma (SIG). This study reported a rapid IOP elevation in a COVID-19 pneumonia child treated with systemic steroids within 3 days. Steroid-induced ocular hypertension (SIOH) during pneumonia treatment has not been previously reported. Case Description: The 6-year-old Chinese girl was diagnosed with COVID-19 and presented with pulmonary exudative lesions. Intravenous steroid (methylprednisolone, 1 mg/kg/12 h) was administered to control the inflammatory reaction on the fourth day post-infection. The child complained of ocular pain in the left eye (OS) after 3 days of steroid application. A high IOP of 40 mmHg in the right eye (OD) and 60 mmHg (OS) was detected. Following the exclusion of elevated IOP secondary to COVID-19 infection, SIOH was considered as a potential etiology. The IOP was effectively controlled through prompt tapering of systemic steroids and the immediate initiation of IOP-lowering therapy, including intravenous mannitol and topical antiglaucoma medications. Conclusions: Clinicians treating COVID-19 in hospitals should pay attention to SIOH or SIG risk, especially in pediatric patients.

Indexed as

case reportcoronavirus disease 2019 (COVID-19)Intraocular pressure (IOP)ocular hypertension (OH)steroid

Identifiers

PMID40225069
PMCPMC11982994

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.