ArticleTranslational cancer research2025
Risk factors, prognostic factors and nomograms for distant metastasis in colorectal neuroendocrine neoplasms: a SEER-based study.
Article in Translational cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Development and internal validation of a SEER-based prediction model for survival in poorly and undifferentiated colorectal neuroendocrine neoplasms.Translational cancer research · 2026Article
- Genetically predicted interleukin 7 levels and neuroblastoma risk combined with analysis of radiation therapy timing effects.Discover oncology · 2025Article
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Authors and funding
6 authors.
Funding
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Abstract
Background: Distant metastasis is uncommon in colorectal neuroendocrine neoplasms (CRNENs). However, the prognosis of patients with distant metastasis is often poor, so it is crucial to detect distant metastasis in time. This article aims to study the risk factors and prognostic factors for the development of distant metastasis in patients with CRNENs and to construct two related nomograms. Methods: Patient data were obtained through the Surveillance, Epidemiology, and End Results (SEER) database, and the inclusion population was identified according to inclusion and exclusion criteria. Logistic regression analysis was used to determine risk factors for distant metastasis in patients with CRNENs. Cox regression analysis was utilized to identify prognostic factors in patients with CRNENs with distant metastasis. Two nomograms were created and the predictive performance of the nomogram was evaluated using receiver operating characteristic (ROC) curves, the calibration curve, and decision curve analysis (DCA) curves. Results: We included 9,142 patients with CRNENs and 859 patients with distant metastasis. Age, race, marital status, primary site, histological grade, T stage, N stage, and tumor size were independent risk factors. Age, primary site, histological grade, N stage, tumor size, dissected lymph nodes, and surgery were independent prognostic factors. The constructed nomogram can predict the occurrence and prognosis of distant metastasis in patients with CRNENs. Conclusions: The nomogram developed in this paper may contribute to the diagnosis and prognosis of distant metastasis in patients with CRNENs and may help clinicians make better clinical decisions.
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