Evidence map›Paper›PMID 40224956›Full record

ReviewJournal of tissue engineering and regenerative medicine2025

Plant-Origin Compounds and Materials for Advancing Bone Tissue Engineering and 3D Bioprinting: Traditional Medicine Aspects and Current Perspectives.

Jyrki Heinämäki, Oleh Koshovyi, Iryna Botsula, Alina Shpychak, Hung Quoc Vo, Hoai Thi Nguyen, Ain Raal

Abstract readReview
In one paragraph

Review in Journal of tissue engineering and regenerative medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Anti-Inflammatory and Antimicrobial Activities of Extracts Developed fromInternational journal of molecular sciences · 2026
    Article
  2. Article
  3. Review
  4. Effects ofJournal of Taibah University Medical Sciences · 2025
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jyrki HeinämäkiInstitute of Pharmacy, Faculty of Medicine, University of Tartu, Tartu, Estonia.ORCID https://orcid.org/0000-0002-5996-5144
Oleh KoshovyiInstitute of Pharmacy, Faculty of Medicine, University of Tartu, Tartu, Estonia.ORCID https://orcid.org/0000-0001-9545-8548
Iryna BotsulaDepartment of Pharmacognosy, National University of Pharmacy, Kharkiv, Ukraine.
Alina ShpychakDepartment of Pharmacognosy, National University of Pharmacy, Kharkiv, Ukraine.
Hung Quoc VoFaculty of Pharmacy, University of Medicine and Pharmacy, Hue University, Hue, Vietnam.
Hoai Thi NguyenFaculty of Pharmacy, University of Medicine and Pharmacy, Hue University, Hue, Vietnam.
Ain RaalInstitute of Pharmacy, Faculty of Medicine, University of Tartu, Tartu, Estonia.ORCID https://orcid.org/0000-0001-8731-7366

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone defects are becoming a true challenge in global health care due to the aging population and higher prevalence of musculoskeletal disorders. The interest in using plant-origin compounds and plant-derived biomaterials in bone tissue engineering (BTE) has been increased due to their availability (abundance), safety, biocompatibility, biodegradability, and low cost. Plant-origin compounds have supportive effects on bone tissue healing, and cell-laden plant-derived biomaterials can be applied in formulating bioinks for three-dimensional (3D) bioprinting to facilitate the preparation of native bone tissue-mimicking structures and customized bone scaffolds. Such plant-derived materials also have the capacity to improve cell viability and support osteoconductive and osteoinductive properties of a bone construct. In this article, we review the ethnomedical aspects related to the use of medicinal plants and plant-origin bioactive compounds in bone healing and the recent developments in the 3D bioprinting of bone constructs with plant-derived biomaterials for advancing BTE. The commonly used 3D-bioprinting techniques, the properties of plant-origin compounds and biomaterials (for bone 3D bioprinting), and the selective examples of bone scaffolds fabricated using plant-derived biomaterials are discussed with a special reference set on applicability, performance, advantages, limitations, and challenges. Plant-origin compounds, biomaterials, and biomimetic 3D-bioprinted constructs could be the basis for a next-generation BTE.

Indexed as

Biocompatible MaterialsBioprintingBone and BonesMedicine, TraditionalPrinting, Three-DimensionalTissue EngineeringAnimalsHumansTissue ScaffoldsBiocompatible Materialsbioinkbone 3D bioprintingbone tissue engineeringmedicinal plantplant-derived biomaterialplant-origin compound

Identifiers

PMID40224956
PMCPMC11985229

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.