ArticleJournal of multidisciplinary healthcare2025
Lack of a Causal Association between DNA Methylation GrimAge Acceleration and Brain Tumor Incidence: A Two-Sample Mendelian Randomization Study.
Article in Journal of multidisciplinary healthcare, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
Objective: To investigate the potential causal relationship between DNA methylation GrimAge acceleration (GAA) and brain tumor incidence using a two-sample Mendelian randomization (MR) approach. Methods: We leveraged publicly available genome-wide association study (GWAS) summary data for GAA (34,467 participants) and brain tumor incidence (491,542 participants). Twenty-six single nucleotide polymorphisms (SNPs) served as instrumental variables for GAA. Inverse variance weighted (IVW) was the primary method, complemented by MR-Egger, weighted median, simple mode, and weighted mode. Sensitivity analyses tested heterogeneity and pleiotropy. Results: The IVW analysis indicated no significant causal effect of GAA on brain tumor risk (β = -0.006, p = 0.908). Other MR methods concurred. Sensitivity checks, including heterogeneity and MR-Egger intercept tests, supported these null findings. Conclusion: Our results do not support a causal association between GrimAge acceleration and brain tumor incidence. Accelerated epigenetic aging, as measured by GAA, may not be a direct driver of brain tumor risk. Further investigations should explore other epigenetic or genetic factors implicated in brain tumor etiology.
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