Evidence map›Paper›PMID 40224643›Full record

ArticleAmerican heart journal plus : cardiology research and practice2025

The clinical impact of prophylactic concomitant left atrial appendage occlusion during cardiac surgery: A systematic review and meta-analysis.

Chengji Zhao, Evaldas Girdauskas, Jan W Schoones, Robert J M Klautz, Meindert Palmen, Anton Tomšič

Abstract read
In one paragraph

Article in American heart journal plus : cardiology research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Iatrogenic atrial dysfunction after prophylactic left atrial appendage exclusion: a proposed post-procedural atrial phenotype.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
  2. Article
  3. Prophylactic surgical left atrial appendage occlusion: More questions than answers!American heart journal plus : cardiology research and practice · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chengji ZhaoDepartment of Cardiothoracic Surgery, Leiden University Medical Centre, Leiden, Netherlands.
Evaldas GirdauskasDepartment of Cardiothoracic Surgery, Augsburg University Medical Centre, Augsburg, Germany.
Jan W SchoonesDirectorate of Research Policy, Leiden University Medical Centre, Leiden, Netherlands.
Robert J M KlautzDepartment of Cardiothoracic Surgery, Leiden University Medical Centre, Leiden, Netherlands.
Meindert PalmenDepartment of Cardiothoracic Surgery, Leiden University Medical Centre, Leiden, Netherlands.
Anton TomšičDepartment of Cardiothoracic Surgery, Leiden University Medical Centre, Leiden, Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Recently, concomitant left atrial appendage occlusion (LAAO) has emerged as prophylactic treatment option for preventing thromboembolic events in patients undergoing cardiac surgery with no known history of atrial fibrillation. The efficacy of prophylactic LAAO remains unknown. Methods: PubMed, Embase, Web of Science, Emcare, and the Cochrane Library were searched for studies on prophylactic LAAO in patients undergoing cardiac surgery. The primary endpoints were postoperative thromboembolic complications and postoperative atrial fibrillation (POAF). Results: Three randomized trials and seven retrospective observational studies were included: in total, 7369 patients received either prophylactic LAAO ( Conclusion: Prophylactic LAAO was associated with a reduction in early and all-time thromboembolic events but demonstrated a potential relation to a higher risk of POAF.

Indexed as

Cardiac surgeryLeft atrial appendageThromboembolic complication

Identifiers

PMID40224643
PMCPMC11987691

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.