ArticleBrain circulation
LINC01492 is associated with susceptibility to large atherosclerotic stroke and levels of inflammatory factors.
Article in Brain circulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Zinc Overload in Microvessels Contributes to Blood-Brain Barrier Disruption by Activating the JAK2 Pathway After Cerebral Ischemia/Reperfusion.CNS neuroscience & therapeutics · 2026Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLINC01492 polymorphism has been implicated in the susceptibility of large artery atherosclerotic (LAA) stroke; however, a dearth of systematic research exists regarding this association in the Asian population at present. SUBJECTS AND
methodsThis study enrolled Han Chinese patients with LAA stroke (n = 428) and age- and sex-matched controls (n = 434). We employed dominant, recessive, and codominant genetic models to analyze the distribution of alleles and genotypes for 14 tag single nucleotide polymorphisms (SNPs) in LINC01492. Furthermore, we quantified the transcript levels of LINC01492 as well as concentrations of inflammatory factors (interleukin [IL]-1β, IL-6, IL-8, IL-10, IL-18, tumor necrosis factor alpha, and CCL18). In addition, we explored the association between these SNPs and levels of inflammatory factors.
resultsThe rs10990654 AA genotype of LINC01492 was markedly associated with a heightened risk of LAA stroke (odds ratio [OR] = 6.403, 95% confidence interval [CI] = 1.180-34.734,
conclusionsThe genetic polymorphisms and transcript levels of LINC01492 exhibit an association with susceptibility to LAA stroke, and the available evidence suggests that this association may be mediated through IL-10 and IL-18.
trial registrationThe trial was registered with the Chinese Clinical Trial Registry (www.chictr.org.cn) under trial registration number ChiCTR2000032684.
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